Treximet (Naproxen/Sumatriptan)

Prescription medicineOnly Available By Prescription

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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
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  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Treximet is a prescription medication for migraine headaches, with or without aura. It is a combination of two active ingredients: naproxen and sumatriptan.

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) known for its pain-relieving and anti-inflammatory properties. Sumatriptan is a selective serotonin receptor agonist that helps to constrict blood vessels in the brain and block the release of certain substances that cause migraine symptoms.

Fact Table






15%(Sumatriptan), 95%(Naproxen)

Legal status


Chemical Name


Elimination half-life

2.5 hours(Sumatriptan), 12–17 hours (Naproxen),

Dosage (Strength)

85mg/500mg (Generic)


Not Recommended



Protein binding

14–21%(Sumatriptan), 99%(Naproxen)

PubChem CID






ATC code






Routes of administration

By mouth


Take one tablet by mouth at the onset of migraine headache symptoms. Take the dosage with a full glass of water. If the migraine is not relieved, a second dose can be taken two hours after the first. Take at most two doses in 24 hours.


The active ingredients in Treximet are naproxen and sumatriptan.


Tell your doctor if you are taking any of the following

  • Abrocitinib
  • Acemetacin
  • Aminolevulinic Acid
  • Antacids
  • Apixaban
  • Bemiparin
  • Bromocriptine
  • Caplacizumab
  • CycloSPORINE
  • Dabigatran Etexilate
  • Diflunisal
  • Edoxaban
  • Enoxaparin
  • Ergot Derivatives
  • Heparin
  • Ketorolac
  • Lithium
  • Loop Diuretics
  • Macimorelin
  • Methotrexate
  • Mifamurtide
  • Monoamine Oxidase Inhibitors
  • Nonsteroidal Anti-Inflammatory Agents
  • Phenylbutazone
  • PRALAtrexate
  • Rivaroxaban
  • Salicylates
  • Selective Serotonin Reuptake Inhibitors
  • Serotonin 5-HT1D Receptor Agonists
  • Sincalide
  • Sucralfate
  • Tenofovir Products
  • Tenoxicam
  • Urokinase
  • Vitamin K Antagonists


Treximet should not be used within 24 hours of taking another medication containing ergotamine or a triptan.

It is important to tell your doctor if you have a history of severe liver or kidney disease.

Tell your doctor if you have a history of any of the following chronic health conditions: uncontrolled high blood pressure, history of heart disease, stroke, seizures, or ulcers.

Side Effects

Common adverse reactions can include

  • Acute myocardial infarction
  • Cerebrovascular accident
  • Chest discomfort
  • Chest pain
  • Coronary thrombosis
  • Dizziness
  • Drowsiness
  • Dyspepsia
  • Gastrointestinal hemorrhage
  • Gastrointestinal perforation
  • Gastrointestinal ulcer
  • Hot flash
  • Hypertonia
  • Jaw pain
  • Jaw pressure
  • Jaw tightness
  • Nausea
  • Neck pain
  • Neck pressure
  • Neck tightness
  • Pharyngeal edema
  • Sore throat
  • Xerostomia


Treximet [package insert]. Research Triangle Park, NC: GlaxoSmithKline ; 2011.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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