Tresiba (Insulin Degludec)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

TRESIBA (insulin degludec) is a long-acting insulin product used to treat high blood sugar (hyperglycemia). TRESIBA is indicated for use in type 1 diabetes mellitus and type 2 diabetes mellitus.

In type 1 diabetes mellitus, patients cannot produce enough of their own insulin. In type 2 diabetes mellitus, patients produce insulin, but their bodies are resistant to the insulin they produce.

TRESIBA is "basal" insulin that provides 24-hour coverage for glycemic control.


TRESIBA is available in or vial or in TRESIBA pens.

Fact Table

Formula

C274H411N65O84

License

US FDA, EMA

Bioavailability

~60%

Legal status

Prescription only (Rx-only)

Chemical Name

Insulin Degludec

Elimination half-life

~25 hours (duration of action >42 hours)

Dosage (Strength)

100 units/mL (U-100), 200 units/mL (U-200); available in 3 mL FlexTouch pens

Pregnancy

Consult a doctor (Category C)

Brands

Tresiba

Protein binding

>99% (to albumin)

PubChem CID

71586665

MedlinePlus

a615035

ChEBI

82721

ATC code

A10AE06

DrugBank

DB08813

KEGG

D10572

Routes of administration

Subcutaneous injection

Directions

The doctor will determine the starting dose of TRESIBA.

Inject TRESIBA insulin subcutaneously once daily at the same time each day.

Rotate injection sites to lower the risk of lipodystrophy.

Ingredients

The active ingredient in TRESIBA is insulin degludec.

Insulin degludec is a long-acting insulin that lasts for about 24 hours in most people.

Interactions

Some medications can raise or lower blood glucose in people with diabetes. You may be at increased risk of poor glucose control if you take any of the following:

  • Alcohol
  • Atypical Antipsychotics
  • Corticosteroids
  • Disopyramide
  • Diuretics
  • Estrogens/Progesterones
  • Fibrates
  • Fluoxetine
  • Isoniazid
  • Lithium
  • Monoamine Oxidase Inhibitors (MAOIs)
  • Niacin
  • Oral antidiabetic agents
  • Pentoxifylline
  • Phenothiazine derivatives
  • Pramlintide
  • Propoxyphene
  • Protease inhibitors
  • Salicylates
  • Somatostatin Analogues
  • Somatropin
  • Sulfonamide Antibiotics
  • Sympathomimetic agents
  • Thyroid replacement medication

Some drugs can hide the signs and symptoms of hypoglycemia. Use caution if you are taking any of the following:

  • Beta-blockers
  • Clonidine
  • Guanethidine
  • Reserpine

Cautions

TRESIBA cannot be used for the treatment of diabetic ketoacidosis.

Do not mix TRESIBA with other insulin products in the same syringe.

Changes to diet, physical activity, or medications may affect blood glucose control.

Side Effects

Some come adverse reactions to TRESIBA may include:

  • Allergic reactions
  • Edema
  • Hypoglycemia
  • Injection site reactions
  • Lipodystrophy
  • Pruritis
  • Rash
  • Weight gain

References

Tresiba [package insert] Plainsboro, NJ: Novo Nordisk; 2015.


Frequently Asked Questions about Tresiba (Insulin Degludec)


Can Tresiba be used in an insulin pump?

No. Tresiba is not approved for use in insulin pumps. It's only for subcutaneous injection using pens or syringes.


How does Tresiba help control A1c?

Tresiba lowers fasting blood glucose levels and stabilizes daily blood sugar, which contributes significantly to a lower A1c (your average 3-month blood sugar level).


Does Tresiba cause weight gain?

Yes, like most insulins, Tresiba can cause modest weight gain, especially when blood sugars normalize. Healthy eating and exercise help manage this.


Can I take Tresiba with oral diabetes medications?

Yes. Tresiba is commonly combined with oral agents like metformin, SGLT2 inhibitors, or DPP-4 inhibitors in type 2 diabetes.


What do I do if I miss a Tresiba dose completely?

If more than 40 hours have passed, take the missed dose as soon as possible. Monitor blood sugar closely and consult your healthcare provider. Avoid taking double doses.


Is Tresiba a good option for people with variable schedules?

Yes. Tresiba's ultra-long action allows for flexible dosing times, making it ideal for shift workers or people with irregular routines.


Can Tresiba be mixed with other insulins?

No. Tresiba should not be mixed with any other insulin or solution. It must be injected separately.


What devices are available for Tresiba?

Tresiba comes in:

FlexTouch pens (prefilled, dial-a-dose)
Available in both U-100 and U-200 strengths


How do I rotate Tresiba injection sites?

Inject into the abdomen, thigh, or upper arm, rotating within the same area to avoid lipodystrophy. Don’t inject into the same exact spot repeatedly.


Is Tresiba safe for people with kidney or liver disease?

Yes, but insulin requirements may change. Tresiba is safe in renal and hepatic impairment, but dosing should be individualized with regular glucose monitoring.

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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