Tracleer (Bosentan)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Tracleer (Bosentan) is an endothelin receptor antagonist. It blocks the effects of endothelin, a substance that constricts blood vessels and raises blood pressure. Tracleer is prescribed to help lower blood pressure within the lungs, a treatment for pulmonary arterial hypertension (PAH). Patients taking Tracleer may find an improvement in their ability to engage in physical activity, and the drug also aims to prevent the worsening of their condition.


Tracleer is taken orally, and the dosage is determined by the healthcare provider based on individual needs and response to the medication. Generally, adults start with 62.5 mg taken twice daily for the first 4 weeks, followed by an increased maintenance dosage of 125 mg twice daily depending on tolerability. It’s important to consult a healthcare provider for exact dosing instructions.


Tracleer contains the active ingredient Bosentan. The medication may also include inactive ingredients, such as corn starch, hydroxypropyl cellulose, low substituted hydroxypropyl cellulose, povidone, and sodium starch glycolate.


The list below details the specific circumstances under which a patient should avoid this medication:

  • Pregnancy: Tracleer carries significant risks of birth defects
  • Use with Cyclosporine A: Increased risk of side effects due to higher levels of Bosentan
  • Use with Glyburide: Can potentially lead to liver injury when taken together
  • Hypersensitivity to Bosentan: Should not be used by individuals with known allergies to this medication


  • Before starting treatment with Tracleer, consult a healthcare provider about the following:
    • Any medications you take
    • Other medical conditions you have
    • Allergies to any medications
    • Whether you’re pregnant or breastfeeding
  • Tracleer has the potential to cause fluid retention, which might necessitate medical intervention. Be alert for signs like swelling in your legs or sudden weight gain, as these could indicate fluid retention.
  • One serious concern is the development of pulmonary veno-occlusive disease (PVOD), a type of lung disease. If you experience symptoms like difficulty breathing or shortness of breath, it could indicate PVOD, and you may need to stop taking Tracleer.
  • It has been noted that Tracleer can reduce sperm count in some patients. This is a crucial consideration for men who plan to have children.
  • Tracleer can cause a decrease in hemoglobin and hematocrit. It's important to check your hemoglobin levels one month and three months after starting treatment and then every three months.

Side Effects

Like other medications, Tracleer may cause certain side effects. The most common side effects include respiratory tract infections, headaches, fainting, flushing, low blood pressure, sinusitis, joint pain, and irregular heartbeats.

Tracleer may also cause potentially severe side effects, such as fluid retention, resulting in swelling of the ankles and legs, and lower sperm counts in men, potentially affecting fertility. Anemia, indicated by low red blood cell levels, is another serious side effect. Patients should report any swelling, difficulty in breathing, or concerns about fertility to their healthcare provider. Regular blood tests are recommended to monitor for anemia. Immediate medical attention may be necessary for severe symptoms.


  1. Tracleer (Bosentan) Product Monograph. San Francisco: Actelion Pharmaceuticals, Inc.; 2023.
  2. Tracleer (Bosentan) Drug Label Information. San Francisco: Actelion Pharmaceuticals, Inc.; 2023.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

product reviews icon Product Reviews