Tolsura (Itraconazole)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Tolsura is a prescription antifungal that can treat a variety of fungal infections. Tolsura works by breaking down the membrane of fungal cells. Breaking the cell membrane causes the cell to die and prevents the organism's growth.

Fact Table







Legal status


Chemical Name


Elimination half-life

21 hours

Dosage (Strength)



Consult Doctor



Protein binding


PubChem CID






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Routes of administration

By mouth


The dosage ranges from 130-260 mg by mouth once daily. Take Tolsura for as long as directed by your healthcare team.

Do not crush or chew this drug.


The active ingredient in Tolsura is itraconazole.


There are many drug-drug interactions with this drug, including:

  • Acalabrutinib
  • Alfuzosin
  • Aliskiren
  • Alprazolam
  • Aprepitant
  • Asciminib
  • Astemizole
  • Asunaprevir
  • Avanafil
  • Avapritinib
  • Barnidipine
  • Bilastine
  • Blonanserin
  • Bosutinib
  • Budesonide
  • Cisapride
  • Clobetasone
  • Cobimetinib
  • Conivaptan
  • CYP3A4 Inducers 
  • Dapoxetine
  • Daridorexant
  • Disopyramide
  • Dofetilide
  • Domperidone
  • Doxorubicin
  • Dronedarone
  • Efavirenz
  • Elagolix, Estradiol, and Norethindrone
  • Eletriptan
  • Eplerenone
  • Ergot Derivatives
  • Estazolam
  • Everolimus
  • Felodipine
  • Finerenone
  • Flibanserin
  • Fluticasone
  • Fosaprepitant
  • Fusidic Acid 
  • Ibrutinib
  • Infigratinib
  • Irinotecan Products
  • Isavuconazonium Sulfate
  • Ivabradine
  • Ivosidenib
  • Lefamulin
  • Lemborexant
  • Lercanidipine
  • Levoketoconazole
  • Lomitapide
  • Lonafarnib
  • Lovastatin
  • Lumateperone
  • Lurasidone
  • Lurbinectedin
  • Macitentan
  • Methadone
  • Midazolam
  • Mitapivat
  • Mizolastine
  • Mobocertinib
  • Naloxegol
  • Neratinib
  • Nevirapine
  • Nimodipine
  • Nisoldipine
  • Pacritinib
  • Pazopanib
  • Pimozide
  • Quinidine
  • Radotinib
  • Ranolazine
  • Red Yeast Rice
  • Regorafenib
  • Rifabutin
  • Rimegepant
  • Rivaroxaban
  • Rupatadine
  • Ruxolitinib
  • Saccharomyces boulardii
  • Salmeterol
  • Silodosin
  • Simeprevir
  • Simvastatin
  • Sirolimus
  • Sonidegib
  • Suvorexant
  • Tamsulosin
  • Tazemetostat
  • Telithromycin
  • Tepotinib
  • Terfenadine
  • Ticagrelor
  • Tolvaptan
  • Topotecan
  • Trabectedin
  • Triazolam
  • Ubrogepant
  • Udenafil
  • Vincristine
  • Vinflunine
  • Voclosporin
  • Vorapaxar

Tell your doctor and pharmacist about all drugs you take before starting Tolsura.


Tell your doctor if you have a history of liver problems, heart arrhythmias, neuropathy, or hearing problems before starting this drug.

Tolsura can cause or worsen heart failure.

Side Effects

Common adverse reactions can include:

  • Abdominal pain
  • Abnormal dreams
  • Abnormal hepatic function tests
  • Anxiety
  • Aphthous stomatitis
  • Bursitis
  • Chest pain
  • Constipation
  • Cough
  • Cystitis
  • Depression
  • Diaphoresis
  • Diarrhea
  • Dizziness
  • Dyspepsia
  • Dyspnea
  • Edema
  • Fever
  • Flatulence
  • Gastritis
  • Gastroenteritis
  • Gastrointestinal disease
  • Fatigue
  • Gingivitis
  • Headache
  • Herpes zoster
  • Hypertension
  • Hypertriglyceridemia
  • Hypokalemia
  • Increased appetite
  • Increased liver enzymes
  • Malaise
  • Myalgia
  • Nausea
  • Pain
  • Pharyngitis
  • Pneumonia
  • Pruritus
  • Rhinitis
  • Sinusitis
  • Skin rash
  • Tremor
  • Upper respiratory tract infection
  • Urinary tract infection
  • Vomiting


Tolsura. Greenville, NC: Mayne Pharma; 2018.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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