Tolak (Fluorouracil topical )

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
4% Cream
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Tolak is a prescription medication for treating actinic keratosis lesions of the face.


Tolak cream should be applied once daily to the face. It can be used for up to four weeks as directed.


The active ingredient in Tolak is fluorouracil.


Common drug-drug interactions include

  • 5-Aminosalicylic Acid Derivatives
  • Abrocitinib
  • Allopurinol
  • Aminolevulinic Acid (Systemic)
  • Aminolevulinic Acid (Topical)
  • Amisulpride (Oral)
  • Antithymocyte Globulin (Equine)
  • Baricitinib
  • BC
  • BCG Products
  • Brincidofovir
  • Brivudine
  • Chloramphenicol (Ophthalmic)
  • Cimetidine
  • Cladribine
  • CloZAPine
  • Coccidioides immitis Skin Test
  • COVID-19 Vaccine (Adenovirus Vector)
  • COVID-19 Vaccine (Inactivated Virus)
  • COVID-19 Vaccine (mRNA)
  • COVID-19 Vaccine (Subunit)
  • COVID-19 Vaccine (Virus-like Particles)
  • Dabrafenib
  • Deferiprone
  • Dengue Tetravalent Vaccine (Live)
  • Denosumab
  • Deucravacitinib
  • Dipyrone
  • Domperidone
  • Fexinidazole
  • Filgotinib
  • Fluorouracil Products
  • Folic Acid
  • Fosphenytoin-Phenytoin
  • Gemcitabine
  • Gimeracil
  • Haloperidol
  • Inebilizumab
  • Influenza Virus Vaccines
  • Interferons (Alfa)
  • Leflunomide
  • Lenograstim
  • Leucovorin Calcium-Levoleucovorin
  • Levoketoconazole
  • Lipegfilgrastim
  • Methoxsalen (Systemic)
  • MetroNIDAZOLE (Systemic)
  • Mumps- Rubella- or Varicella-Containing Live Vaccines
  • Nadofaragene Firadenovec
  • Natalizumab
  • Ocrelizumab
  • Ofatumumab
  • Olaparib
  • Ondansetron
  • Palifermin
  • Pentamidine (Systemic)
  • Pidotimod
  • Pimecrolimus
  • Pimozide
  • Pneumococcal Vaccines
  • Poliovirus Vaccine (Live/Trivalent/Oral)
  • Polymethylmethacrylate
  • Porfimer
  • Promazine
  • QT-prolonging Agents
  • Rabies Vaccine
  • Ritlecitinib
  • Ropeginterferon Alfa-2b
  • Ruxolitinib (Topical)
  • Sertindole
  • Sipuleucel-T
  • Sphingosine 1-Phosphate (S1P) Receptor Modulator
  • Tacrolimus (Topical)
  • Talimogene Laherparepvec
  • Tertomotide
  • Tofacitinib
  • TOLBUTamide
  • Typhoid Vaccine
  • Ublituximab
  • Upadacitinib
  • Vaccines (Inactivated/Non-Replicating)
  • Vaccines (Live)
  • Verteporfin
  • Vitamin K Antagonists (e.g., warfarin)
  • Yellow Fever Vaccine


There are many possible cautions with this medication. Speak to your doctor or pharmacist for a complete list of side effects.

Side Effects

Common adverse reactions include:

  • Agranulocytosis
  • Alopecia
  • Anaphylaxis
  • Angina pectoris
  • Anemia
  • Cardiac arrhythmia
  • Cardiac failure
  • Cerebellar syndrome (acute)
  • Cerebrovascular accident
  • Changes in nails (including nail loss)
  • Confusion
  • Dermatitis
  • Diarrhea
  • Disorientation
  • Dysgeusia (Syed 2016)
  • Epistaxis
  • Euphoria
  • Gastrointestinal hemorrhage
  • Gastrointestinal ulcer
  • Headache
  • Hyperpigmentation (supravenous)
  • Hypersensitivity reaction (generalized)
  • Ischemic heart disease
  • Lacrimal stenosis
  • Lacrimation
  • Leukopenia (nadir: days 9 to 14; recovery by day 30)
  • Local thrombophlebitis
  • Maculopapular rash (pruritic)
  • Mesenteric ischemia (acute)
  • Myocardial infarction
  • Nausea
  • Nystagmus
  • Palmar-plantar erythrodysesthesia
  • Pancytopenia
  • Photophobia
  • Skin fissure
  • Skin photosensitivity
  • Stevens-Johnson syndrome
  • Stomatitis
  • Thrombocytopenia
  • Tissue sloughing (gastrointestinal)
  • Toxic epidermal necrolysis
  • Vasospasm
  • Ventricular ectopy
  • Visual disturbance
  • Vomiting
  • Xeroderma


Tolak [package insert]. Sanford, Florida: Hill Dermaceuticals; 2015.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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