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Tofidence (Tocilizumab)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Tofidence, known generically as tocilizumab-bavi, is a biosimilar to the drug Actemra. Tofidence works by blocking the activity of interleukin-6 (IL-6), a protein involved in the inflammatory process. It is classified as an IL-6 receptor antagonist and administered as intravenous (IV) infusion under the supervision of a healthcare provider. Tofidence may be used to treat various forms of arthritis, including rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, and systemic juvenile idiopathic arthritis.

Directions

Tofidence is administered as an IV infusion, which a healthcare provider typically oversees. The standard dosages can vary based on the conditions being treated such as rheumatoid arthritis or juvenile idiopathic arthritis. The dosage may also be adjusted according to patient-specific factors like weight and the severity of symptoms.

Tofidence should not be started in people with an absolute neutrophil count (ANC) under 2000 per mm³, a platelet count below 100,000 per mm³, or if liver enzyme levels – ALT or AST – are more than 1.5 times the upper limit of normal. Work closely with a healthcare provider who can monitor your health while receiving Tofidence.

Ingredients

The active ingredient in Tofidence is tocilizumab-bavi. However, it may include inactive ingredients that act as preservatives and help maintain the stability and pH of the solution. These inactive ingredients may include histidine, sucrose, polysorbate 80, and water for injection.

Contraindications

Tofidence should not be used in people with a history of allergies or hypersensitivity to tocilizumab or any ingredient of the medication.

Cautions

  • Before taking Tofidence, tell your doctor about:
    • All medications you take, including prescription, over-the-counter, and herbal medicines.
    • Any medical conditions.
    • If you have a known allergy to any medications.
  • Tofidence has been linked with serious infections, potentially leading to hospitalization or death. These include tuberculosis (TB), bacterial, fungal, and viral infections. If you develop a serious infection while using Tofidence, the treatment should be temporarily stopped until the infection is effectively managed.
  • Before starting Tofidence, you may need a test for latent TB. If you test positive, treatment for TB should be completed prior to starting Tofidence. Even if the initial TB test is negative, watch for signs of active TB during the course of treatment.
  • Tofidence should not be used if you have an active infection present. In case of a serious infection, the use of Tofidence must be discontinued until the infection is under control.
  • If you are at an elevated risk of gastrointestinal (GI) perforation, use caution when using Tofidence.
  • Watch for signs of liver damage. Tofidence treatment may need to be adjusted or stopped if liver test results are consistently abnormal or if symptoms of liver disease appear.
  • Regular laboratory tests are recommended due to potential changes in neutrophils, platelets, lipids, and liver enzymes that can occur due to treatment with Tofidence.
  • Be aware of the possibility of hypersensitivity reactions, including anaphylaxis, which can be severe and occasionally fatal.
  • While undergoing treatment with Tofidence, avoid receiving live vaccines.

Side Effects

Tofidence may cause various side effects. Common tocilizumab side effects include respiratory infections such as a common cold, headaches, high blood pressure, and injection site reactions like redness, itching, or pain.

Serious side effects of Tofidence can be more concerning and require immediate medical attention. These include a hepatitis B infection and allergic reactions. Seek medical attention if you experience signs of a hepatitis B infection, such as fatigue, vomiting, black or tarry stools, bloody or cloudy urine, and chills, or signs of an allergic reaction, such as dizziness, stomach pain, and difficulty breathing.

References:

Tofidence (Tocilizumab) Product Monograph. Cambridge, MA: Biogen MA Inc; 2023.




IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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