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| Strength | Pack Size | Qty | |
|---|---|---|---|
|
Strength
10mg
|
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tavneos (avacopan) is a medicine for adults with severe, active forms of ANCA-associated vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). These rare autoimmune diseases cause the immune system to attack small blood vessels, which can damage the kidneys, lungs, and other organs. Avacopan blocks a receptor involved with inflammation in these conditions. It is used along with other treatments and may help reduce the amount of steroid medicine needed.
| Fact Table |
|
| Formula |
C33H35F4N3O2 |
| License |
US FDA (NDA 214487; initial approval 2021; withdrawal proposed in 2026, pending final action) |
| Bioavailability |
Absolute bioavailability unknown |
| Legal status |
Rx-only (US) |
| Chemical Name |
(2R,3S)-2-[4-(cyclopentylamino)phenyl]-1-(2-fluoro-6-methylbenzoyl)-N-[4-methyl-3-(trifluoromethyl)phenyl]piperidine-3-carboxamide |
| Elimination half-life |
97.6 hours; active metabolite M1: 55.6 hours |
| Dosage (Strength) |
10 mg capsules; recommended dosage: 30 mg (three capsules) orally twice daily with food; 30 mg once daily with strong CYP3A4 inhibitors |
| Pregnancy |
No adequate and well-controlled studies in pregnant women; consult a doctor. Animal studies showed increased abortions in rabbits |
| Brands |
Tavneos |
| Protein binding |
>99.9% |
| PubChem CID |
49841217 |
| MedlinePlus |
a622023 |
| ChEBI |
756375 |
| ATC code |
L04AJ05 |
| DrugBank |
DB15011 |
| KEGG |
D11093 |
| Routes of administration |
Oral |
Take Tavneos as 30 mg (three 10 mg capsules) twice daily with food. Swallow the capsules whole. Do not crush, chew, or open them. If you miss a dose, skip it and take your normal dose at the next scheduled time. Do not take two doses at once.
Before treatment starts, a healthcare provider will check your liver function and test for hepatitis B. Liver tests are usually repeated about every four weeks for the first six months. Continue taking Tavneos with your other vasculitis medicines unless your healthcare provider tells you otherwise.
The active ingredient in Tavneos is avacopan. Inactive ingredients may include polyethylene glycol 4000 and polyoxyl-40 hydrogenated castor oil. The capsule shell contains gelatin, red iron oxide, yellow iron oxide, and titanium dioxide, and the sealing band contains gelatin and polysorbate 80.
Avoid taking or using this medication if there is a known history of a serious hypersensitivity reaction to avacopan or to any of the other ingredients in the capsule.
Common side effects of Tavneos include:
Get medical help for swelling of the face, lips, tongue, or throat, trouble breathing, or hives, which can be signs of a serious allergic reaction. Contact a healthcare provider about signs of liver injury such as yellowing of the skin or eyes, dark urine, pale stools, itching, pain on the right side of the abdomen, nausea, or unusual tiredness. Fever, chills, a persistent cough, or any other sign of infection should also be reported, as Tavneos is often used together with medications that can lower the body’s ability to fight infection.
Tavneos Prescribing Information. Thousand Oaks, CA: ChemoCentryx, Inc.; 2024.
Tavneos Drug Label Information. Thousand Oaks, CA: ChemoCentryx, Inc.; 2026.
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