Taltz (Ixekizumab)

Description

Taltz, also known by the generic name Ixekizumab, is an injectable medication used to treat autoimmune diseases. It is approved for moderate-to-severe plaque psoriasis, active psoriatic arthritis, and active ankylosing spondylitis. This medication belongs to the class of humanized monoclonal antibodies and works by binding to and neutralizing interleukin 17A, a molecule involved in inflammation.

Directions

Follow the proper steps when using Taltz to ensure its effectiveness and safety. Before starting the injection process, carefully read and follow the step-by-step instructions provided by the manufacturer. Your healthcare provider or nurse will show you how to prepare and inject Taltz using the autoinjector or prefilled syringe. When preparing to use Taltz, remember to follow these guidelines:

• Ensure the medication is stored at the correct temperature and inspect the solution for any visible particles or discoloration.
• Wash your hands thoroughly and clean the injection site with an alcohol swab before administering the medication.
• If using the autoinjector, uncap the pen and remove the needle cover by pulling it straight off.
• Place the autoinjector or prefilled syringe against the skin at a 90-degree angle, and inject the medication by following the device's specific instructions.
• Press and hold the device at the injection site for the recommended amount of time to ensure the full dose is administered.
• Dispose of the used device in a proper sharps container as advised by your healthcare provider.

Regular monitoring and follow-up appointments with your healthcare provider can allow you to track the progress and effectiveness of the treatment. Make sure to inform your doctor of any side effects or concerns that may arise during the treatment course.

Ingredients

The active ingredient in Taltz is Ixekizumab. In addition to Ixekizumab, Taltz may contain other inactive ingredients, such as sodium hydroxide and polysorbate 80. These substances are included to help stabilize the drug formulation, improve its shelf life, and improve its effectiveness in the body.

Contraindications

People with a history of severe allergic reactions to Ixekizumab or any of its components should not use Taltz. Another contraindication for Taltz is the administration of certain live vaccines.

Cautions

• Before starting Taltz (Ixekizumab) treatment, consider the following with a healthcare provider:
• Any medications you take
• Other medical conditions you have
• All allergies you have
• Whether you are pregnant or breastfeeding
• If you get any symptoms of a serious infection, like a high fever, persistent cough, or significant tiredness, contact your doctor right away. If a serious infection happens, you'll need to stop taking Taltz until you're better.
• Your doctor will check for tuberculosis, also known as TB, before you start Taltz. If you've had TB before, make sure to tell your doctor.
• If you have a serious allergic reaction to Taltz, like trouble breathing, hives, or swelling of your face, lips, tongue, or throat, stop taking the medicine and get medical help immediately.
• Taltz may cause issues with your stomach, like Crohn’s disease or ulcerative colitis. If you already have these conditions, Taltz might make them worse. If your stomach problems start up or get worse, you may need to stop Taltz and get medical care.
• Avoid vaccinations that contain live viruses while using Taltz. Talk to your doctor about which vaccines are safe for you.

Side Effects

When taking Taltz (Ixekizumab), be mindful of possible adverse reactions. The medication is often well-tolerated, but some people might experience issues at the site of injection or develop fungal infections like athlete's foot. Taltz side effects may also include respiratory infections such as sinus infections or seasonal flu, as well as feelings of nausea.

There are also instances of more serious health concerns linked to Taltz. Individuals may develop or notice a worsening of inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, which can lead to persistent diarrhea, abdominal discomfort, and unintended weight loss. In addition, serious allergic reactions may occur, with symptoms like skin rashes, constriction in the chest, difficulty breathing, and facial swelling.

References:

1. Taltz (Ixekizumab) Product Monograph. Indianapolis, IN: Eli Lilly; 2022.
2. Taltz (Ixekizumab) Drug Label Information. Indianapolis, IN: Eli Lilly; 2022.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....