Taldefgrobep

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Taldefgrobep alfa is a fully human recombinant protein designed to inhibit myostatin and activin A signaling—two key regulators of muscle mass and adipose tissue. By binding to myostatin and acting as an activin receptor antagonist, it aims to increase muscle mass and reduce fat accumulation. Taldefgrobep is being developed as an adjunctive therapy for spinal muscular atrophy (SMA) and is also under investigation for potential use in obesity management.

Directions

Taldefgrobep alfa is administered via subcutaneous injection. In the RESILIENT Phase 3 trial for SMA, dosing was conducted over a 48-week period. Specific dosing regimens are determined based on patient weight and clinical protocol. The therapy is intended as an adjunct to existing SMA treatments such as nusinersen, risdiplam, or onasemnogene abeparvovec-xioi. Administration should be supervised by healthcare professionals experienced in managing neuromuscular disorders.

Ingredients

Active ingredient:

  • Taldefgrobep alfa (BHV-2000), a fully human recombinant protein engineered to bind myostatin and inhibit activin receptor signaling.

Inactive ingredients:

  • Specific excipients have not been publicly disclosed; formulation details are proprietary to the manufacturer.

Contraindications

As of the latest clinical data, no specific contraindications have been identified. However, patients with known hypersensitivity to recombinant proteins or any component of the formulation should exercise caution. Further evaluation is ongoing to establish comprehensive safety profiles.

Cautions

  • Myostatin Levels: Efficacy may be limited in individuals with low or undetectable baseline myostatin levels, as observed in certain SMA subpopulations.
  • Genetic Variability: Genetic factors, including SMN2 copy number and race-related polymorphisms, may influence treatment response.
  • Combination Therapy: Taldefgrobep is intended for use alongside existing SMA therapies; interactions and cumulative effects should be monitored.
  • Pediatric Use: While trials have included participants aged 4 to 21 years, long-term effects in pediatric populations require further study.

Side Effects

In clinical trials, taldefgrobep alfa was generally well-tolerated. Reported side effects include:

  • Injection site reactions
  • Mild gastrointestinal symptoms
  • Fatigue

No treatment-related serious adverse events (SAEs) were reported in the RESILIENT trial, and 97% of participants continued into the optional long-term extension phase.

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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