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Tafinlar (Dabrafenib)

Prescription medicineOnly Available By Prescription
Sezzle

Top brand choice

Strength Pack Size Qty
Strength
50mg
Pack Size
Qty

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Your doctor may prescribe Tafinlar to treat advanced melanoma, a type of skin cancer. It is a kinase inhibitor that targets the BRAF protein, which is involved in the growth and spread of cancer cells.

Tafinlar is often used with another medication, Mekinist (trametinib), for treating melanoma that has spread to other parts of the body or cannot be surgically removed.


Fact Table

Formula

C23H20F3N5O2S2

License

US DailyMed, EU EMA

Bioavailability

95%

Legal status

Rx-Only

Chemical Name

Dabrafenib

Elimination half-life

8 hours

Dosage (Strength)

-

Pregnancy

Consult Doctor

Brands

Tafinlar

Protein binding

99.7%

PubChem CID

44462760

MedlinePlus

a613038

ChEBI

75045

ATC code

L01EC02

DrugBank

DB08912

KEGG

D10064

Routes of administration

By mouth

Directions

The usual dosage is 150 mg orally twice daily with or without food. Do not crush, chew, or break the tablets.

Ingredients

The active ingredient in Tafinlar is dabrafenib.

Interactions

The most common interactions occur between Tafinlar and:

  • Abemaciclib
  • Alfentanil
  • Aminolevulinic Acid
  • Antihepaciviral Combination Products
  • Asunaprevir
  • Atogepant
  • Avacopan
  • Avanafil
  • Avapritinib
  • Axitinib
  • Bedaquiline
  • Bosutinib
  • Brigatinib
  • Capmatinib
  • Cariprazine
  • Clarithromycin
  • Cobimetinib
  • CYP2C8 Inhibitors
  • CYP3A4 Inhibitors
  • Daclatasvir
  • Daridorexant
  • Dasabuvir
  • Deflazacort
  • Disopyramide
  • Domperidone
  • DOXOrubicin
  • Dronedarone
  • Duvelisib
  • Elbasvir and Grazoprevir
  • Encorafenib
  • Entrectinib
  • Erdafitinib
  • Fedratinib
  • Fexinidazole
  • Finerenone
  • Flibanserin
  • Fusidic Acid
  • Ganaxolone
  • Glasdegib
  • GuanFACINE
  • Hormonal Contraceptives
  • Ibrexafungerp
  • Indinavir
  • Infigratinib
  • Ivabradine
  • Larotrectinib
  • Lefamulin
  • Lemborexant
  • Lenacapavir
  • Levoketoconazole
  • Lonafarnib
  • Lorlatinib
  • Lumateperone
  • Lurasidone
  • Lurbinectedin
  • Maraviroc
  • Mavacamten
  • Methadone
  • Mitapivat
  • Mobocertinib
  • Neratinib
  • Nisoldipine
  • Olaparib
  • Olutasidenib
  • Orelabrutinib
  • Pacritinib
  • Pemigatinib
  • Perampanel
  • Pimavanserin
  • Pimozide
  • Praziquantel
  • Pretomanid
  • QT-prolonging Agents
  • QT-prolonging Strong CYP3A4 Inhibitors
  • QuiNIDine
  • QuiNINE
  • Ranolazine
  • Rimegepant
  • Ripretinib
  • Selpercatinib
  • Selumetinib
  • Sertindole
  • Simeprevir
  • Sonidegib
  • Tazemetostat
  • Ubrogepant
  • Ulipristal
  • Vandetanib
  • Velpatasvir
  • Venetoclax
  • Voclosporin
  • Vonoprazan
  • Vorapaxar
  • Voxelotor
  • Voxilaprevir
  • Zanubrutinib

Cautions

Tafinlar may cause serious side effects, including skin cancer, new or worsening squamous cell carcinoma of the skin, or a type of inflammation called colitis. You should tell your doctor if you have a previous history of skin cancer or inflammatory bowel disease before starting treatment with Tafinlar.

Ask your healthcare team about a complete list of side effects that apply to you.

Side Effects

Tell your doctor or pharmacist if you experience any of the following:

  • Alopecia
  • Arthralgia
  • Back pain
  • Basal cell carcinoma of the skin
  • Bullous rash
  • Chills
  • Constipation
  • Cough
  • Dizziness
  • Fatigue
  • Febrile reaction
  • Fever
  • Headache
  • Hyperglycemia
  • Hyperkeratosis
  • Hyponatremia
  • Hypophosphatemia
  • Increased serum alkaline phosphatase
  • Interstitial nephritis
  • Kaposi sarcoma
  • Keratoacanthoma
  • Malignant melanoma
  • Malignant neoplasm
  • Myalgia
  • Nasopharyngitis
  • Palmar-plantar erythrodysesthesia
  • Pancreatitis
  • Papilloma
  • Skin rash
  • Squamous cell carcinoma of skin
  • Uveitis
  • Xeroderma

References

  1. Tafinlar [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2014.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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