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Synvisc (Hylan GF 20)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


SYNVISC (Hylan G-F 20) is a medication prescribed to treat knee pain in patients with osteoarthritis. Osteoarthritis is a degenerative disease of the joints where the protective cartilage around the ends of bones wears down, causing pain when the bones move against each other.

SYNVISC injection can only be administered by a medical professional in a clinic, hospital, or another healthcare setting. SYNVISC should never be self-administered.


SYNVISC is administered by a healthcare professional using an aseptic technique. SYNVISC 2 mL is injected intraarterially into the knee joint once weekly for three weeks.

SYNVISC injection has not been shown to be safe for injections other than the knee.


SYNVISC contains the polymers Hylan A and Hylan B, which are cross-linked to form a long-chain polymer that contains repeating disaccharide units of sodium-glucuronate-N-acetylglucosamine. Hylan A and Hylan B are derivatives of the naturally occurring hyaluronan.

Hyaluronan plays a role in joint lubrication and tissue repair in joints and skin tissue. It occurs naturally throughout the body, but over time can degrade, especially in patients with osteoarthritis.


Do not use SYNVISC if you have an allergy to hyaluronan or to avian proteins, feathers, or egg products. SYNVISC injection is made from chicken cells.

Do not use SYNVISC if you have inflammation or infection in the knee joint or surrounding skin tissue.

SYNVISC should be stored at room temperature and should not be refrigerated or frozen. Protect SYNVISC from light by keeping it in its original packaging. SYNVISC should not be used if the packaging has been opened or damaged.

Side Effects

Some of the adverse effects of SYNVISC may include:

  • Chills
  • Difficulty breathing
  • Dizziness
  • Fever
  • Fluid build-up around the knee
  • Headache
  • Heat
  • Hives
  • Itching
  • Muscle pain
  • Pain
  • Rash
  • Redness
  • Swelling
  • Thrombocytopenia

SYNVISC can only be ordered and administered with the prescription of a doctor or other licensed healthcare professional. Before ordering SYNVISC, ensure that your healthcare provider is able and willing to administer the injection in their facility.


  1. Synvisc [package insert]. Ridgefield, NJ 07657: Genzyme; 2014.
  2. Mayo Clinic, Osteoarthritis, February 22nd, 2020. Retrieved April 2020.
  3. Healthline, Aseptic Technique, June 23rd, 2017. Retrieved April 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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