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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Synjardy XR (empagliflozin and metformin hydrochloride extended-release) contains two drugs and is used with diet and exercise to treat type 2 diabetes in adult patients.
Synjardy XR comes in oral tablets of the following strengths:
Take Synjardy XR as prescribed by your doctor. Notify your doctor or pharmacist about any questions or concerns you may have.
Each patient's Synjardy XR dose depends on their kidney function and current treatment regimen.
Generally, the dose is to take one tablet by mouth one time a day. It's recommended to take it with breakfast. The maximum recommended dose is 25 mg empagliflozin/2,000 mg metformin HCl daily. Swallow the tablet whole; avoid crushing, chewing, or splitting it.
If you're having iodinated contrast imaging, you may need to stop taking Synjardy XR at the time of, or before, receiving the procedure.
Empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor and metformin hydrochloride, a biguanide, is contained in each Synjardy XR tablet.
Polyethylene oxide, hypromellose, and magnesium stearate are the inactive ingredients. Hypromellose, titanium dioxide, polydextrose, polyethylene glycol, talc, carnauba wax, purified water, ferrosoferric oxide, propylene glycol, isopropyl alcohol, ferric oxide yellow (5 mg/1,000 mg; 10 mg/1,000 mg; 25 mg/1,000 mg), ferric oxide red (10 mg/1,000 mg), and FD and C blue#2/indigo carmine aluminum lake (12.5 mg/1,000 mg; 25 mg/1,000 mg) make up the tablet film coating and ink.
Patients should avoid treatment with Synjardy XR if they have severe kidney problems, metabolic acidosis, or an allergy to empagliflozin, metformin, or any of the other ingredients.
Synjardy XR has FDA Boxed Warnings regarding cases of lactic acidosis associated with metformin that led to death, hypothermia, low blood pressure, and resistant, slow heart arrhythmias. Patients who have kidney problems, are using certain medications, are 65 years old or older, have radiological studies with contrast, have surgery or other procedures, have low oxygen levels, consume excessive amounts of alcohol, or have liver problems may be at increased risk.
Urinary tract infection, fungal infection in the genital areas, diarrhea, nausea, vomiting, gas, stomach discomfort, indigestion, headache, and weakness are common Synjardy XR side effects. However, these are not all the side effects that can be caused by Synjardy XR.
Tell your doctor immediately if you have side effects that are bothersome or persistent.