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Stiolto Respimat (Tiotropium Bromide / Olodaterol)

Also Known as Spiolto

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
2.5mcg/2.5mcg (60 puffs/30 doses/inhaler)
Pack Size
2.5mcg/2.5mcg (60 puffs/30 doses/inhaler)
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Stiolto Respimat (tiotropium bromide and olodaterol inhalation spray) is used in adults for long-term maintenance of chronic obstructive pulmonary disease (COPD).

Stiolto Respimat contains two medications that help open up the airways to allow for easier breathing: tiotropium bromide, an anticholinergic, and olodaterol, a long-acting beta2-adrenergic agonist.

Stiolto Respimat is not used for treating acute deterioration of COPD.

Stiolto Respimat is not used to treat asthma.

Fact Table







Legal status


Chemical Name

Tiotropium Bromide / Olodaterol

Elimination half-life

7.5 hours

Dosage (Strength)

2.5mcg/2.5mcg (60 puffs/30 doses/inhaler)


Consult Doctor


Stiolto Respimat

Protein binding


PubChem CID






ATC code






Routes of administration



Follow the instructions that come with your Stiolto Respimat prescription. Don't hesitate to talk to your doctor or pharmacist about any questions or concerns you have about your prescription.

Stiolto Respimat comes in an inhalation spray for inhalation use. 2.5 mcg of tiotropium and 2.5 mcg of olodaterol is provided in each puff. 

Recommended dosage:

Inhale two puffs by mouth one time a day at the same time each day. 


Tiotropium bromide, an anticholinergic, and olodaterol, a beta2-adrenergic agonist, are the active ingredients in Stiolto Respimat. 

Water for injection, benzalkonium chloride, edetate disodium, and hydrochloric acid are the inactive ingredients contained in Stiolto Respimat.


Using Stiolto Respimat without an inhaled corticosteroid is not recommended in patients with asthma.

Avoid using Stiolto Respimat if you are allergic to tiotropium, ipratropium, olodaterol, or any of the other ingredients in Stiolto Respimat.


  • Before starting COPD treatment with Stiolto Respimat, talk to your doctor:
    • About your allergies
    • About your medical conditions
    • About all the medications you take
    • About your pregnancy or breastfeeding status
  • Patients who have acutely deteriorating COPD, a serious and potentially life-threatening condition, should not use Stiolto Respimat. Discuss your COPD with your doctor. 
  • Do not use Stiolto Respimat to relieve sudden breathing problems.
  • The recommended dose of Stiolto Respimat should not be exceeded. 
  • Severe and potentially life-threatening cardiovascular problems can occur by using Stiolto Respimat with other medications that have long-acting beta2-adrenergic agonists.
  • Severe allergic reactions can occur with the use of Stiolto Respimat. Stop using Stiolto Respimat and get emergency care right away if you have swelling, itching, rash, difficulty breathing, bronchospasm, or any other effects.
  • Paradoxical bronchospasm that may be life-threatening can occur with the use of Stiolto Respimat.
  • If you have cardiovascular or convulsive issues, problems with your thyroid, or if you are unable to take sympathomimetic drugs, use Stiolto Respimat with caution. 
  • Glaucoma can be worsened with the use of Stiolto Respimat. If you have glaucoma, use the medication with caution.
  • Urinary retention can worsen with the use of Stiolto Respimat. If you have prostatic hyperplasia or bladder-neck obstruction, use the medication with caution.
  • Low potassium and high blood sugar levels can occur with the use of Stiolto Respimat. 

Side Effects

Stiolto Respimat can cause nasopharyngitis, cough, and back pain. The medication can also cause other side effects, so call your doctor right away if you have side effects that get worse or won't go away.


Stiolto Respimat (tiotropium bromide and olodaterol inhalation spray), for oral inhalation use. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2021.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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