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Sitavig (Acyclovir)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Your doctor may prescribe Sitavig to treat herpes labialis (cold sores). It contains the antiviral medication acyclovir and helps to reduce the symptoms of cold sores and treat outbreaks.

Cold sores are an infection of the mouth and lips that are caused by the herpes simplex virus. Once infected, the herpes virus stays in the infected tissue and can periodically cause symptoms. Normally, the immune system will suppress the infection, but cold sores can "flare" if a person's immune system is weakened.

Sitavig works by incorporating into the genetic material of the virus, preventing it from replicating and infecting other tissue.

Fact Table







Legal status


Chemical Name


Elimination half-life

2–4 hours

Dosage (Strength)



No Known Risk


Sitavig, Zovirax

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


Sitavig is a buccal tablet and should be placed between the gums and the cheek.

Place one 50 mg buccal tablet in the upper gum region within one hour of the onset of symptoms.

Do not crush, chew, suck, or swallow Sitavig.

It is okay to eat or drink while using Sitavig.


The active ingredient in Sitavig is acyclovir.

Store Sitavig at room temperature in a cool, dry place.


Since Sitavig is a buccal tablet, only very low amounts absorb into the bloodstream and drug interactions are not common. Use caution if you are taking the following:

  • Talimogene Laherparepvec


Use caution if you have a documented allergy to milk or milk products.

Tell your doctor if you are pregnant or planning to become pregnant.

Side Effects

Common side effects of this medication may include:

  • Anaphylaxis
  • Angioedema
  • Aphthous stomatitis
  • Application site irritation
  • Burning skin
  • Contact dermatitis
  • Cracked lips
  • Desquamation
  • Dry lips
  • Dryness of skin
  • Eczema
  • Erythema
  • Flakiness of skin
  • Gingival pain
  • Lethargy 
  • Local pain
  • Localized edema
  • Pruritus
  • Skin rash
  • Stinging on skin
  • Transient burning


Sitavig. Charleston, SC: EPI Health LLC; 2019.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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