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Strength
1mg
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Sintrom is an oral anticoagulant containing acenocoumarol, a vitamin K antagonist (VKA) used for the prevention and treatment of thromboembolic disorders, including deep vein thrombosis (DVT), pulmonary embolism (PE), and prevention of stroke in patients with atrial fibrillation, prosthetic heart valves, or other conditions associated with increased risk of thrombosis. Acenocoumarol inhibits vitamin K epoxide reductase, reducing the synthesis of active clotting factors II, VII, IX, and X, and proteins C and S.
| Fact Table | |
| Formula | C19H15NO6 |
| License | EMA; Not FDA-approved |
| Bioavailability | ~60% to 100% |
| Legal status | Prescription only |
| Chemical Name | (RS)-4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one |
| Elimination half-life | ~8–11 hours |
| Dosage (Strength) | 1 mg, 2 mg, 4 mg tablets (titrated to INR) |
| Pregnancy | Category X – contraindicated in pregnancy |
| Brands | Sintrom, Sinthrome, Acenocoumarol (generic) |
| Protein binding | ~98% |
| PubChem CID | 1987 |
| MedlinePlus | Not listed (not marketed in U.S.) |
| ChEBI | CHEBI:135206 |
| ATC code | B01AA07 |
| DrugBank | DB01418 |
| KEGG | D07199 |
| Routes of administration | Oral |
Sintrom is administered orally once daily, typically at the same time each day.
Therapeutic onset is delayed; bridging with heparin may be required for acute indications. Patients must maintain consistent dietary vitamin K intake and avoid abrupt changes in medications that may interact with VKAs.
Each tablet contains:
Inactive ingredients may include:
Sintrom is contraindicated in:
Close INR monitoring is essential, especially when initiating therapy, changing dose, or introducing interacting medications (e.g., antibiotics, antifungals, NSAIDs, antiplatelets, or other anticoagulants). Use with caution in patients with renal impairment, liver disease, alcoholism, or poor compliance. Patients should be educated on signs of bleeding, the importance of consistent vitamin K intake, and the need to inform healthcare providers of any new medications or dietary changes.
Common and potential side effects include:
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