Simparica Trio (Sarolaner, Moxidectin, Pyrantel)


Top brand choice

Strength Pack Size Qty
Dog 2.8-5.5 lbs (Gold Box)
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Dog 5.6-11 lbs (Purple Box)
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Dog 11.1-22 lbs (Caramel Box)
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Dog 22.1-44 lbs (Teal Box)
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Dog 44.1-88 lbs (Green Box)
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Dog 88.1-132 lbs (Brown Box)
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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Simparica TRIO (sarolaner, moxidectin, and pyrantel) is a flavored, chewable oral tablet for dogs that are at least 8 weeks old and weigh at least 2.8 pounds, used by or on the order of a licensed veterinarian to:

  • Prevent heartworm disease
  • Treat roundworms and hookworms
  • Prevent and treat fleas
  • Treat ticks
  • Prevent Borrelia burgdorferi infections caused by the killing of Ixodes scapularis vector ticks


Your veterinarian will give you instructions on administering Simparica TRIO to your dog that you should follow. If you have any questions or concerns, talk to your veterinarian. 

Give Simparica TRIO to your dog by mouth once a month with or without food. Dosing is based on your dog's weight. Discuss dosing with your veterinarian before beginning treatment with Simparica TRIO to ensure that your dog receives an appropriate dose.


The active ingredients included in each tablet are sarolaner, moxidectin, and pyrantel. 


  • Before your dog begins treatment with Simparica TRIO, tell your veterinarian:
    • If your dog takes any medications
    • About any allergies your dog may have
    • About any health conditions your dog may have
    • About your dog's pregnancy or nursing status
  • Humans, cats, or other animals should not take Simparica TRIO
  • Sarolaner, an active ingredient in Simparica TRIO, can cause neurological effects such as tremors, incoordination, and seizures. Use Simparica TRIO with caution if your dog has a history of seizures or neurologic problems.

Side Effects

Simparica TRIO side effects include the following: vomiting, diarrhea, lack of energy, decreased appetite, excessive urination, hyperactivity, and excessive thirst. If you notice your dog developing concerning side effects, immediately call your veterinarian. 

Looking for a great price on Simparica TRIO for dogs? You can buy Simparica TRIO for dogs with a valid prescription from your veterinarian and online at a competitive cost at Canada Drugs Direct.


Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets). Kalamazoo, MI: Zoetis Inc.; 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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