Known as Simbrinza Ophthalmic Suspension in the UK
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Simbrinza Ophthalmic 1%/0.2% is a combination of ophthalmic medication used to treat intraocular pressure in either ocular hypertension or open-angle glaucoma. Simbrinza contains the active ingredients of brinzolamide and brimonidine. Each medication works by a different mechanism to reduce ocular pressure.
Patients with glaucoma have abnormally high pressure in their eyes that can cause damage to the optic nerves. If left untreated, glaucoma can cause permanent damage and loss of vision.
Instill one drop into the affected eye or eyes three times daily.
Separate the administration of Simbrinza from other eye drops by at least five minutes.
While using Simbrinza, do not touch the tip of the eye dropper directly to the eye or other nonsterile surfaces. Contamination of the eyedropper may cause microbial growth that can lead to infection of the eye.
Brinzolamide is a carbonic anhydrase inhibitor. Carbonic anhydrase II is an enzyme in the ocular tissue that is responsible for the transport of sodium and fluid. By inhibiting carbonic anhydrase II, brinzolamide decreases the formation of bicarbonate ions and downstream secretion of aqueous humor.
Brimonidine is an alpha-2 receptor agonist. Alpha-2 receptors in the eye are responsible for reducing intraocular pressure, and brimonidine activates this system, easing the symptoms of glaucoma and ocular hypertension.
Brinzolamide is a sulfonamide drug that can be absorbed systemically. Patients with sulfa drug allergies should use caution when using Simbrinza.
Contact lenses should be removed during the use of Simbrinza and can be replaced 15 minutes after medication use. The preservative benzalkonium chloride may absorb into contact lenses.
Patients with a history of cardiovascular disease should speak with their doctor before using Simbrinza.
The most common side effects of Simbrinza may include:
This is not a complete list of side effects. Speak with your doctor about your full medical history before using Simbrinza.
A prescription is required when buying Simbrinza online. Your doctor can provide a prescription to buy Simbrinza online from Canada Drugs Direct. Compare Simbrinza cost to your local pharmacy.