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Also Known as Simbrinza Ophthalmic Suspension
Only Available By Prescription
Top brand choice
| Strength | Pack Size | Qty | |
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Strength
1%/0.2% 5ml
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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using
Top Generic choice
| Strength | Pack Size | Qty | |
|---|---|---|---|
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Strength
1%/0.2% 5ml
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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using
We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Simbrinza Ophthalmic 1%/0.2% is a combination of ophthalmic medication used to treat intraocular pressure in either ocular hypertension or open-angle glaucoma. Simbrinza contains the active ingredients of brinzolamide and brimonidine. Each medication works by a different mechanism to reduce ocular pressure.
Patients with glaucoma have abnormally high pressure in their eyes that can cause damage to the optic nerves. If left untreated, glaucoma can cause permanent damage and loss of vision.
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Fact Table |
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Formula |
Brinzolamide: C12H21N3O5S3 Brimonidine: C11H10BrN5 |
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License |
EU EMA, US DailyMed |
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Bioavailability |
Brinzolamide: Absorbed systemically, but below detectable levels (less than 10 ng/mL) Brimonidine: Not Available |
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Legal status |
Prescription only |
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Chemical Name |
Brinzolamide/Brimonidine Tartrate |
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Elimination half-life |
111 days (Brinzolamide), Brimonidine: 3 hours (ocular), 12 hours (topical) |
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Dosage (Strength) |
1% / 0.2% 5ml |
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Pregnancy |
Consult Doctor |
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Brands |
Simbrinza Opthalmic |
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Protein binding |
60% |
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PubChem CID |
68844 |
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MedlinePlus |
a601233 |
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ChEBI |
3176 |
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ATC code |
S01EC04 |
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DrugBank |
DB01194 |
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KEGG |
D00652 |
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Routes of administration |
Ophthalmic |
Instill one drop into the affected eye or eyes three times daily.
Separate the administration of Simbrinza from other eye drops by at least five minutes.
While using Simbrinza, do not touch the tip of the eye dropper directly to the eye or other nonsterile surfaces. Contamination of the eyedropper may cause microbial growth that can lead to infection of the eye.
Brinzolamide
Brinzolamide is a carbonic anhydrase inhibitor. Carbonic anhydrase II is an enzyme in the ocular tissue that is responsible for the transport of sodium and fluid. By inhibiting carbonic anhydrase II, brinzolamide decreases the formation of bicarbonate ions and downstream secretion of aqueous humor.
Brimonidine
Brimonidine is an alpha-2 receptor agonist. Alpha-2 receptors in the eye are responsible for reducing intraocular pressure, and brimonidine activates this system, easing the symptoms of glaucoma and ocular hypertension.
Brinzolamide is a sulfonamide drug that can be absorbed systemically. Patients with sulfa drug allergies should use caution when using Simbrinza.
Contact lenses should be removed during the use of Simbrinza and can be replaced 15 minutes after medication use. The preservative benzalkonium chloride may absorb into contact lenses.
Patients with a history of cardiovascular disease should speak with their doctor before using Simbrinza.
The most common side effects of Simbrinza may include:
This is not a complete list of side effects. Speak with your doctor about your full medical history before using Simbrinza.
Exceptional Customer Service
We pride ourselves on delivering excellent customer service with as much accessibility as possible.
If you have any questions at all, or would like to place an order, you are encouraged to contact us by toll-free
phone 1-888-904-8467 or email info@canadadrugsdirect.com.
Top Safety and Quality
Canada Drugs Direct employs dedicated, professional licensed pharmacists to ensure that each and every order is reviewed before it is dispensed for the safety and health of our customers. At CanadaDrugsDirect.com, your health is our top priority.
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