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Simbrinza Opthalmic (Brinzolamide/Brimonidine Tartrate)

Also Known as Simbrinza Ophthalmic Suspension

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
1%/0.2% 5ml
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

Top Generic choice

Strength Pack Size Qty
1%/0.2% 5ml
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Simbrinza Ophthalmic 1%/0.2% is a combination of ophthalmic medication used to treat intraocular pressure in either ocular hypertension or open-angle glaucoma. Simbrinza contains the active ingredients of brinzolamide and brimonidine. Each medication works by a different mechanism to reduce ocular pressure.

Patients with glaucoma have abnormally high pressure in their eyes that can cause damage to the optic nerves. If left untreated, glaucoma can cause permanent damage and loss of vision.

Fact Table


Brinzolamide: C12H21N3O5S3 Brimonidine: C11H10BrN5


EU EMA, US DailyMed


Brinzolamide: Absorbed systemically, but below detectable levels (less than 10 ng/mL) Brimonidine: Not Available

Legal status

Prescription only

Chemical Name

Brinzolamide/Brimonidine Tartrate

Elimination half-life

111 days (Brinzolamide), Brimonidine: 3 hours (ocular), 12 hours (topical)

Dosage (Strength)

1% / 0.2% 5ml


Consult Doctor


Simbrinza Opthalmic

Protein binding


PubChem CID






ATC code






Routes of administration



Instill one drop into the affected eye or eyes three times daily.

Separate the administration of Simbrinza from other eye drops by at least five minutes.

While using Simbrinza, do not touch the tip of the eye dropper directly to the eye or other nonsterile surfaces. Contamination of the eyedropper may cause microbial growth that can lead to infection of the eye.



Brinzolamide is a carbonic anhydrase inhibitor. Carbonic anhydrase II is an enzyme in the ocular tissue that is responsible for the transport of sodium and fluid. By inhibiting carbonic anhydrase II, brinzolamide decreases the formation of bicarbonate ions and downstream secretion of aqueous humor.


Brimonidine is an alpha-2 receptor agonist. Alpha-2 receptors in the eye are responsible for reducing intraocular pressure, and brimonidine activates this system, easing the symptoms of glaucoma and ocular hypertension.


Brinzolamide is a sulfonamide drug that can be absorbed systemically. Patients with sulfa drug allergies should use caution when using Simbrinza.

Contact lenses should be removed during the use of Simbrinza and can be replaced 15 minutes after medication use. The preservative benzalkonium chloride may absorb into contact lenses.

Patients with a history of cardiovascular disease should speak with their doctor before using Simbrinza.

Side Effects

The most common side effects of Simbrinza may include:

  • Blurred vision
  • Dry mouth
  • Dysgeusia
  • Eye allergy
  • Eye irritation

This is not a complete list of side effects. Speak with your doctor about your full medical history before using Simbrinza. 


  1. FDA. "Simbrinza Package Insert." Published 2013. Accessed December 7, 2019.
  2. Weinreb RN, Aung T, Medeiros FA. "The Pathophysiology and Treatment of Glaucoma." JAMA. 2014;311(18):1901. doi:10.1001/jama.2014.3192

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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