Seysara (Sarecycline)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Seysara (sarecycline) is a narrow-spectrum tetracycline-class antibiotic indicated for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients aged 9 years and older. Unlike broader-spectrum tetracyclines, sarecycline is designed with targeted antibacterial activity against Cutibacterium acnes, while minimizing activity against many Gram-negative gut flora, potentially reducing gastrointestinal side effects and antibiotic resistance. Its once-daily oral dosing and favorable safety profile make it a convenient and effective option for long-term acne management.

Fact Table

Formula

C24H29N3O8

License

US FDA (2018)

Bioavailability

~60%

Legal status

Prescription only

Chemical Name

Sarecycline

Elimination half-life

21–22 hours

Dosage (Strength)

60 mg, 100 mg, 150 mg oral tablets

Pregnancy

Contraindicated – may cause fetal harm

Brands

Seysara

Protein binding

~62.5%

PubChem CID

71703361

MedlinePlus

a619054

ChEBI

145441

ATC code

J01AA15

DrugBank

DB12158

KEGG

D11137

Routes of administration

Oral

Directions

Seysara is administered orally once daily, with or without food. The dosage is weight-based:

  • 60 mg for patients 33–54 kg
  • 100 mg for patients 55–84 kg
  • 150 mg for patients 85–136 kg

Tablets should be swallowed whole with a full glass of water and not crushed or chewed. Treatment duration should be as short as possible and re-evaluated periodically. Concomitant use of antacids or supplements containing aluminum, calcium, or magnesium should be spaced apart by at least 1–2 hours due to potential absorption interference.

Ingredients

Each Seysara tablet contains:

  • Sarecycline hydrochloride, equivalent to 60 mg, 100 mg, or 150 mg sarecycline

Inactive ingredients include:

  • Microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, and film-coating agents such as titanium dioxide and polyethylene glycol

Contraindications

Seysara is contraindicated in:

  • Patients with known hypersensitivity to tetracyclines
  • Children under 8 years of age due to risk of permanent tooth discoloration and enamel hypoplasia
  • Pregnant or breastfeeding women, due to potential fetal harm and bone growth inhibition

Cautions

Use of sarecycline may result in photosensitivity; patients should avoid excessive sunlight or UV exposure and use protective measures. Intracranial hypertension has been reported with tetracyclines and should be monitored in patients presenting with visual symptoms. Prolonged use may lead to the overgrowth of non-susceptible organisms, including fungi. Patients should be monitored for signs of superinfection. The safety of long-term use beyond 12 weeks has not been established.

Side Effects

Common and potential side effects include:

  • Nausea
  • Headache
  • Vomiting
  • Photosensitivity
  • Vaginal candidiasis
  • Rare: hypersensitivity reactions, intracranial hypertension, pseudotumor cerebri

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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