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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Serzone (nefazodone hydrochloride) is an oral antidepressant indicated for the treatment of major depressive disorder (MDD) in adults. It is classified as a serotonin antagonist and reuptake inhibitor (SARI). Nefazodone works by inhibiting the reuptake of serotonin and norepinephrine and antagonizing 5-HT2A receptors, thereby improving mood and alleviating depressive symptoms. Unlike many other antidepressants, Serzone has a relatively low incidence of sexual side effects and does not typically cause significant weight gain. Due to the risk of serious liver injury, its use is restricted and has been discontinued in several countries, including Canada and parts of Europe, though it may still be available in the U.S. under specific conditions.
| Fact Table | |
| Formula | C25H32ClN5O2 |
| License | US FDA (withdrawn in 2004) |
| Bioavailability | ~20% (due to first-pass metabolism) |
| Legal status | Withdrawn in the U.S.; available in some countries |
| Chemical Name | Nefazodone hydrochloride |
| Elimination half-life | 2–4 hours (parent); 18 hours (active metabolite) |
| Dosage (Strength) | 100 mg, 150 mg, 200 mg, 250 mg tablets (oral) |
| Pregnancy | Category C – risk cannot be ruled out |
| Brands | Serzone, generic nefazodone (limited availability) |
| Protein binding | >99% |
| PubChem CID | 4433 |
| MedlinePlus | a697014 |
| ChEBI | 7503 |
| ATC code | N06AX11 |
| DrugBank | DB01149 |
| KEGG | D08206 |
| Routes of administration | Oral |
Serzone is administered orally, with an initial recommended dose of 100 mg twice daily, gradually titrated up based on clinical response and tolerability. The usual therapeutic dose ranges from 300 mg to 600 mg per day, divided into two doses. The maximum recommended dose is 600 mg/day. It may be taken with or without food. Dosage adjustments are required in patients with hepatic or renal impairment. Abrupt discontinuation should be avoided; tapering is advised to reduce the risk of withdrawal symptoms.
Each tablet of Serzone contains:
Nefazodone hydrochloride, equivalent to 100 mg, 150 mg, 200 mg, or 250 mg of nefazodone base
Inactive ingredients may include:
Microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose, and various colorants depending on tablet strength
Serzone is contraindicated in patients with:
Active liver disease or history of nefazodone-induced hepatic injury
Known hypersensitivity to nefazodone or phenylpiperazine derivatives
Concurrent use of cisapride, pimozide, triazolam, or carbamazepine due to risk of serious interactions
Concurrent use of MAO inhibitors or within 14 days of discontinuing an MAOI
Serzone carries a boxed warning for life-threatening hepatic failure, including reports of liver transplants and deaths. Liver function tests should be performed before treatment and periodically thereafter. Patients should be educated on signs of liver dysfunction (e.g., jaundice, dark urine, fatigue) and instructed to discontinue the drug immediately if symptoms arise. Nefazodone is a strong CYP3A4 inhibitor, and caution is required when used with other CYP3A4 substrates. Monitor for suicidal thoughts or behavior, particularly at the beginning of therapy or during dose adjustments.
Common and potential side effects include:
Drowsiness or sedation
Dry mouth
Nausea
Dizziness
Constipation
Blurred vision
Sexual dysfunction (less common than SSRIs)
Rare: hepatotoxicity, orthostatic hypotension, priapism, serotonin syndrome (with serotonergic agents)
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