Serzone (Nefazodone)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Serzone (nefazodone hydrochloride) is an oral antidepressant indicated for the treatment of major depressive disorder (MDD) in adults. It is classified as a serotonin antagonist and reuptake inhibitor (SARI). Nefazodone works by inhibiting the reuptake of serotonin and norepinephrine and antagonizing 5-HT2A receptors, thereby improving mood and alleviating depressive symptoms. Unlike many other antidepressants, Serzone has a relatively low incidence of sexual side effects and does not typically cause significant weight gain. Due to the risk of serious liver injury, its use is restricted and has been discontinued in several countries, including Canada and parts of Europe, though it may still be available in the U.S. under specific conditions.

Fact Table

Formula

C25H32ClN5O2

License

US FDA (withdrawn in 2004)

Bioavailability

~20% (due to first-pass metabolism)

Legal status

Withdrawn in the U.S.; available in some countries

Chemical Name

Nefazodone hydrochloride

Elimination half-life

2–4 hours (parent); 18 hours (active metabolite)

Dosage (Strength)

100 mg, 150 mg, 200 mg, 250 mg tablets (oral)

Pregnancy

Category C – risk cannot be ruled out

Brands

Serzone, generic nefazodone (limited availability)

Protein binding

>99%

PubChem CID

4433

MedlinePlus

a697014

ChEBI

7503

ATC code

N06AX11

DrugBank

DB01149

KEGG

D08206

Routes of administration

Oral

Directions

Serzone is administered orally, with an initial recommended dose of 100 mg twice daily, gradually titrated up based on clinical response and tolerability. The usual therapeutic dose ranges from 300 mg to 600 mg per day, divided into two doses. The maximum recommended dose is 600 mg/day. It may be taken with or without food. Dosage adjustments are required in patients with hepatic or renal impairment. Abrupt discontinuation should be avoided; tapering is advised to reduce the risk of withdrawal symptoms.

Ingredients

Each tablet of Serzone contains:

Nefazodone hydrochloride, equivalent to 100 mg, 150 mg, 200 mg, or 250 mg of nefazodone base

Inactive ingredients may include:

Microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose, and various colorants depending on tablet strength

Contraindications

Serzone is contraindicated in patients with:

Active liver disease or history of nefazodone-induced hepatic injury

Known hypersensitivity to nefazodone or phenylpiperazine derivatives

Concurrent use of cisapride, pimozide, triazolam, or carbamazepine due to risk of serious interactions

Concurrent use of MAO inhibitors or within 14 days of discontinuing an MAOI

Cautions

Serzone carries a boxed warning for life-threatening hepatic failure, including reports of liver transplants and deaths. Liver function tests should be performed before treatment and periodically thereafter. Patients should be educated on signs of liver dysfunction (e.g., jaundice, dark urine, fatigue) and instructed to discontinue the drug immediately if symptoms arise. Nefazodone is a strong CYP3A4 inhibitor, and caution is required when used with other CYP3A4 substrates. Monitor for suicidal thoughts or behavior, particularly at the beginning of therapy or during dose adjustments.

Side Effects

Common and potential side effects include:

Drowsiness or sedation

Dry mouth

Nausea

Dizziness

Constipation

Blurred vision

Sexual dysfunction (less common than SSRIs)

Rare: hepatotoxicity, orthostatic hypotension, priapism, serotonin syndrome (with serotonergic agents)

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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