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Santyl Ointment (Collagenase)

Prescription medicineOnly Available By Prescription

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Santyl ointment is a debriding ointment used to treat chronic dermal ulcers. Debriding ointments are designed to remove foreign material, remove dead skin, and clean a wound. Santyl ointment helps to speed up the natural healing process.

Dermal ulcers are sore or open wounds that develop on the skin. Ulcers happen when there is poor blood flow to a section of the skin. Without proper blood flow, the outer layer may turn red, become painful, or fall off.

Santyl works by utilizing collagenase, an enzyme naturally occurring in the body. Collagenase breaks down collagen in dead skin tissue, which helps to remove it since collagen composes the majority of skin cells dry weight.


Santyl is typically administered by wound care professionals. If you have been prescribed Santyl to be used at home, this treatment should be accompanied by the appropriate wound care.

  1. Prior to application, the wound should be cleaned with a gauze pad saturated with a saline rinse
  2. If there is an infection, the appropriate antibiotic should be applied
  3. Apply Santyl ointment to a gauze pad and place it on the wound or apply it directly to the wound


The active ingredient in Santyl Ointment is collagenase, which is a naturally occurring enzyme. 


There are no known significant interactions.


Do not mix Santyl ointment with other creams or ointments for application. An improper pH may render the ointment inert.

Clean and rinse the area thoroughly with saline rinse prior to application of Santyl.

Side Effects

Common side effects of collagenase Santyl may include:

  • Application site burning
  • Application site irritation
  • Application site pain
  • Hypersensitivity reaction

Buy Santyl ointment from Canada Drugs Direct.


Collagenase santyl [package insert]. Fort Worth, TX: Smith & Nephew, Inc; 2019.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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