Ryaltris Nasal Spray (Olopatadine/Mometasone)

Prescription medicineOnly Available By Prescription

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Strength Pack Size Qty
600mcg/25mcg 240 Doses
Pack Size

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Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Ryaltris Nasal Spray (olopatadine hydrochloride and mometasone furoate) is used to treat seasonal allergies in adults and pediatric patients who are 12 years of age and older.

Ryaltris comes in a bottle with a spray pump that dispenses a specific amount of 665 mcg of olopatadine hydrochloride and 25 mcg of mometasone furoate with each spray.

Ryaltris is for nasal use only.

Fact Table


C21H23NO3 (Olopatadine), C27H30O6Cl2(Mometasone)




57%(Olopatadine), Less than 1% (Mometasone)

Legal status


Chemical Name


Elimination half-life

9 and 18 hours

Dosage (Strength)

600mcg / 25mcg 240 Doses


Consult Doctor


Ryaltris Nasal Spray

Protein binding

98% to 99%

PubChem CID

5281071 (Olopatadine), 441335 (Mometasone)


a602025 (Olopatadine)


6970 (Mometasone)

ATC code



DB00768(Olopatadine), DB00764(Mometasone)



Routes of administration

Nasal spray


It is recommended that you read the patient information and instructions for use that come with your prescription. Ryaltris should be used as directed by your doctor. Any questions or concerns about the medication may be referred to your doctor or pharmacist.

Before you use Ryaltris, shake the bottle well.

You’ll need to prime the pump before you use Ryaltris for the first time or if you have not used Ryaltris in the past 14 days. Start by pointing the tip away from your eyes and face. Then, quickly but firmly push down on the pump six times until a fine mist appears.

Ryaltris Nasal Spray dosage:

Your doctor will instruct you on how many sprays you should use and how often you should use Ryaltris. Patients typically use two sprays in each nostril two times a day.

How to use Ryaltris

First, clear your nostrils by gently blowing your nose. Next, use a finger to close one nostril while you place the nasal tip into the other nostril, aiming it slightly toward the outside of your nose. Tilt your head forward a little and quickly press down on the finger rests once to activate the pump. Gently breathe through your nose as your spray, then breathe out through your mouth.

In order to prevent the medicine from going into your throat, avoid tipping your head back right after using. Give yourself at least 15 minutes after using Ryaltris before blowing your nose.

Clean the nasal tip of the bottle with a clean dry tissue or cloth.

Ryaltris should be stored upright with the dust cap on at room temperatures between 20°C and 25°C (68°F and 77°F). Avoid freezing or refrigerating the medication.


Olopatadine hydrochloride, an antihistamine, and mometasone furoate, a corticosteroid, are the active ingredients in Ryaltris Nasal Spray.

Benzalkonium chloride, carboxymethylcellulose sodium, dibasic sodium phosphate heptahydrate, edetate disodium, hydrochloric acid, microcrystalline cellulose, polysorbate 80, sodium chloride, sodium hydroxide, and water for injection are the inactive ingredients.


Avoid using Ryaltris if you have an allergy to any of the ingredients contained in the medication.


  • Before using Ryaltris, inform your doctor of the following:
    • All the medications you use, including other nasal sprays and allergy medications
    • Your allergies
    • Your current health conditions and past medical history
    • Your pregnancy or breastfeeding status
  • Avoid driving, operating machinery, or doing other activities that can be hazardous until you know how you tolerate Ryaltris.
  • Nosebleeds, nasal ulceration, septal perforation, delayed nasal wound healing, and local nasal and pharyngeal infections can occur with Ryaltris use.
  • Vision changes, including glaucoma and/or cataracts, can occur with Ryaltris use.
  • The immune system may be weakened by Ryaltris. This can make people more susceptible to infections or worsening of infections.
  • Hypercorticism and adrenal suppression can occur with Ryaltris use, especially when using doses that are higher than recommended.
  • Because growth in pediatric patients can be affected by Ryaltris use, the medication should not be given to patients under 12 years of age.

Side Effects

Ryaltris can cause side effects that include, but are not limited to, unpleasant taste, nosebleeds, and nasal discomfort. Immediately let your doctor know if you develop bothersome or persistent side effects.


Ryaltris. Columbus, OH: Hikma Specialty USA Inc.; 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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