Rowasa Enema (Mesalamine)

Also Known as Salofalk Enema

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Rowasa (mesalamine) is a rectal suspension enema for treating adults who suffer from mild to moderate distal ulcerative colitis, proctosigmoiditis, or proctitis. 

Fact Table







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Chemical Name


Elimination half-life

5 hours

Dosage (Strength)

2g/60ml, 4g/60ml




Rowasa Enema

Protein binding


PubChem CID






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Routes of administration



You should follow the instructions on the label of your prescription and read the package insert that comes with your prescription. If you have any questions or concerns, talk to your doctor or pharmacist. 

Rowasa Rectal Suspension Enema comes in disposable bottles that are wrapped in foil trays. 

Insert one Rowasa enema rectally once daily at night before you go to bed. 

To ensure that the suspension is mixed well, shake the bottle. Remove the applicator tip's protective cover while holding the neck of the bottle. To help with balance, it is recommended to lie on the left side with the left leg stretched out and the upper right leg bent forward. You may alternatively use the knee-chest position. 

Gently place the tip of the applicator into the rectum. The applicator tip should point toward the navel. Consistently squeeze the bottle to ensure that you get the optimal amount of medication delivered. Dispose of the used bottle. 

Remain in the same position for at least 30 minutes. If possible, retain the enema throughout the entire night. 

It is important to stay hydrated during treatment.


Each Rowasa Rectal Suspension Enema consists of 4 grams of mesalamine in 60 mL aqueous suspension.

Carbomer 934P, edetate disodium, potassium acetate, potassium metabisulfite, purified water, and xanthan gum are the inactive ingredients. Sodium benzoate is used as a preservative. There is a protective cover over the applicator tip that contains polyethylene and USP white petrolatum for lubrication. 


Avoid using Rowasa if you are allergic to salicylates, aminosalicylates, sulfites, or any other ingredient in Rowasa.


  • Before beginning treatment with Rowasa enema, tell your doctor:
    • About any allergies you may have
    • About any medications you may take
    • About your health problems or conditions
    • If you are pregnant or breastfeeding
  • Serious, fatal allergic reactions can occur with Rowasa. Immediately seek emergency care if you begin to have trouble breathing, swelling of the face, lips, mouth, or tongue, rash, or itchiness. 
  • Kidney problems can be caused by Rowasa.
  • Acute intolerance syndrome that is similar to the symptoms a flare up of inflammatory bowel disease, causing cramps, stomach pain, blood diarrhea, fever, headache, and rash can be caused by Rowasa. If you experience any of these effects, immediately tell your doctor.
  • Liver failure can be caused by Rowasa.
  • Photosensitivity can be caused by Rowasa. During treatment with Rowasa, it is recommended to avoid sun exposure, wear protective clothing, and apply a broad-spectrum when you go outside.
  • Kidney stones can be caused by Rowasa.
  • Lab abnormalities can be caused by Rowasa.
  • Drug interactions can occur with the following medications: non-steroidal anti-inflammatory drugs, azathioprine, and 6-mercaptopurine.

Side Effects

Immediately tell your doctor if you begin to experience troublesome or persistent side effects. The most common side effects associated with Rowasa are the following: stomach pain, cramps, headache, gas, nausea, flu, tiredness, fever, rash, cold, sore throat, diarrhea, leg pain, joint pain, dizziness, bloating, back pain, pain upon enema insertion, hemorrhoids, itching, rectal pain, constipation, hair loss, peripheral swelling, urinary tract infection, burning upon urination, lack of energy, and trouble sleeping.


Rowasa (mesalamine) Rectal Suspension Enema 4.0 grams/unit (60 mL). Somerset, NJ: Meda Pharmaceuticals; 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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