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Rhofade (Oxymetazoline HCI)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
1% Cream
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Rhofade is a prescription cream used for persistent facial redness from rosacea. It is approved for treatment in adults patients. Your healthcare provider may have prescribed this drug if you have tried and failed other treatments.

Rosacea is a skin condition where a person develops redness and flushing caused by visible blood vessels in the face. Symptoms also include papules, eye problems, and thickened skin. It is most common in middle-aged women with fair skin.

Rhofade works by reducing the appearance of blood vessels. Rhofade constricts (tightens) blood vessels of the face, making them less visible.

Fact Table







Legal status

Rx-Only (topical cream)

Chemical Name


Elimination half-life

5–6 hours

Dosage (Strength)



No Known Risks


Afrin, Ocuclear, Drixine, Rhofade

Protein binding

56.7% to 57.5%

PubChem CID






ATC code






Routes of administration



Apply Rhofade in a pea-sized amount to the entire face.

Wash hands thoroughly with soap and water after using this drug.

Do not get this medication in the mouth, eyes, or vagina.

The bottle should be primed at least three times before using it for the first time to ensure the drug is flowing through the bottle appropriately.


The active ingredient in Rhofade is oxymetazoline.


Drug-drug interactions are uncommon when using topical medications because only small amounts are absorbed into the body. However, some people may be at higher risk if they use the drug for a long period or in very high doses.

Tell your pharmacist and doctor about all medications you are taking, including:

  • Bromocriptine
  • Cocaine (topical)
  • Ergot derivatives
  • Esketamine
  • Iobenguane radiopharmaceutical products 
  • Kratom
  • Linezolid
  • Lisuride
  • Monoamine oxidase inhibitors


Tell your doctor if you have a history of cardiovascular disease before starting this drug. Rhofade contains an alpha-agonist medication, which constricts blood vessels and can worsen certain conditions. 

Use caution if you have a history of narrow-angle glaucoma when starting this drug.

Side Effects

Common adverse reactions that can occur with Rhofade may include:

  • Application site dermatitis
  • Application site erythema
  • Application site pain
  • Exacerbation of acne rosacea


Rhofade cream. Irvine, CA: Allergan; 2017.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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