Rheumate (L-5,Curcumin,Vitamin b-12)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Rheumate is a prescription medical food prescribed to people who are taking methotrexate therapy to manage rheumatic conditions like rheumatoid arthritis. Methotrexate is a folate antagonist, and it works by starving diseased cells of folic acid so they cannot continue to replicate. People who take methotrexate must take folic acid supplementation, so the other cells of their body do not experience the toxic effects of methotrexate. 

Rheumate is not a prescription drug but is classified as a medical food. It should only be used under the supervision of a physician or another healthcare professional.


The usual dosage is one to two capsules by mouth once or twice a day. Do not change the dosage without speaking to your doctor.

The dosage may change during the course of methotrexate therapy depending on if there are changes to the methotrexate dose.


Rheumate contains three different active ingredients:

The folate works by replenishing the lost folate when taking methotrexate. This type of folate works better for people with methyltetrahydrofolate reductase (MTHFR) deficiency.

Vitamin B12 (methylcobalamin) is present in Rheumate because replenishing folate can hide the symptoms of certain types of anemia.

Turmeric (curcumin) is a known antioxidant that reduces the liver damage caused by methotrexate. It scavenges reactive oxygen species (ROS) and helps to reduce inflammation.


Tell your doctor and pharmacist if you are taking the following drugs before starting Rheumate:

  • Atorvastatin
  • Fluvastatin
  • Lovastatin
  • Oral contraceptives
  • Phenytoin
  • Pravastatin
  • Pitavastatin
  • Rosuvastatin
  • Simvastatin
  • Sulfasalazine
  • Tetracycline
  • Warfarin


Do not take this medical food if you have an allergy to any of the ingredients, including folic acid (vitamin B9), methylcobalamin (vitamin B12), or turmeric (curcumin).

Side Effects

The most common side effects may include:


Rheumate. Scottsdale, AZ: Primus Pharmaceuticals, Inc.; 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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