Remdesivir

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Remdesivir is a nucleotide analog prodrug with broad-spectrum antiviral activity, approved for the treatment of COVID-19 caused by SARS-CoV-2 in hospitalized and non-hospitalized patients. It functions by inhibiting the RNA-dependent RNA polymerase (RdRp), thereby interfering with viral RNA replication. Initially developed for Ebola virus, remdesivir has been repurposed and studied extensively in the treatment of COVID-19 and is the first antiviral to receive full FDA approval for this indication in the United States. Clinical trials have shown it can reduce time to recovery in hospitalized patients with moderate to severe disease.

Fact Table

Formula

C27H35N6O8P

License

US FDA (2020)

Bioavailability

Not applicable (IV only)

Legal status

Prescription only

Chemical Name

Remdesivir

Elimination half-life

~1 hour (parent); ~25 hours (active metabolite GS-441524)

Dosage (Strength)

100 mg lyophilized powder or solution for IV infusion

Pregnancy

Use only if clearly needed; limited human data

Brands

Veklury

Protein binding

~88–93%

PubChem CID

121304016

MedlinePlus

a620046

ChEBI

CHEBI:145994

ATC code

J05AB16

DrugBank

DB14761

KEGG

D11874

Routes of administration

Intravenous (IV infusion)

Directions

Remdesivir is administered by intravenous infusion under medical supervision. The standard adult dosing for COVID-19 is:

Loading dose: 200 mg on Day 1

Maintenance dose: 100 mg once daily on Days 2–5 (up to 10 days in severe cases)

Each dose should be infused over 30 to 120 minutes, depending on the formulation. Dosing adjustments may be required for renal or hepatic impairment. It is not recommended in patients with eGFR <30 mL/min, unless benefits outweigh risks. Remdesivir should be initiated as early as possible in the disease course, ideally within 7 days of symptom onset.

Ingredients

Remdesivir is supplied as:

Lyophilized powder (100 mg/vial) or solution (100 mg/20 mL vial) for IV infusion

Each vial contains:

Remdesivir 100 mg

Inactive ingredients include:

Betadex sulfobutyl ether sodium (SBECD) as a solubilizing agent

Water for injection and pH adjusters (depending on formulation)

Contraindications

Remdesivir is contraindicated in patients with:

Known hypersensitivity to remdesivir or any excipients

Severe renal impairment (eGFR <30 mL/min) due to accumulation of SBECD, unless clinically justified

Cautions

Monitor liver function during treatment, as transaminase elevations and rare cases of hepatotoxicity have been reported. Use with caution in patients with pre-existing liver disease. Monitor renal function, especially in patients with borderline renal function. Discontinue if ALT levels rise to >10× ULN or if accompanied by signs of liver inflammation. The safety of use in pregnant or breastfeeding women has not been fully established; use only if the potential benefit outweighs risk. Remdesivir should not be co-administered with chloroquine or hydroxychloroquine due to antagonistic effects on antiviral activity.

Side Effects

Common and potential side effects include:

Nausea

Elevated ALT and AST

Headache

Hypersensitivity or infusion-related reactions (fever, hypotension, chills)

Rare: renal toxicity, bradycardia, or rash

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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