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Ranexa (Ranolazine ER)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


RANEXA (Ranolazine ER) is a medication prescribed for the treatment of chronic angina. RANEXA is often prescribed for patients who have tried and failed beta-blockers due to side effects, for those who cannot take beta-blockers or those in whom beta-blockers have failed.

Angina is a chronic condition where the arteries of the heart do not carry enough oxygen to supply cardiac cells. Angina feels like pressure or squeezing in the chest and the pain may radiate to other parts of the body like the shoulders, jaw, and neck.

RANEXA works by altering the flow of sodium ions through the cell membranes of heart muscle cells. Altering sodium ion flow also changes the number of calcium ions inside the cells. When the concentration of calcium ions is lowered, the tension in the heart ventricles is reduced, lowering how much oxygen heart cells consume.


Take RANEXA 500 mg by mouth twice daily with or without food. The dose may be increased to 1000 mg twice daily based on efficacy and side effects.

Do not drink grapefruit juice while taking this medication.


The active ingredient and name for RANEXA generic is Ranolazine ER (extended-release).


RANEXA has the potential to interact with many medications. Review your medication list with your pharmacist and doctor before starting RANEXA.

RANEXA may increase the QT interval, which is a measure of electrical conductivity in the heart. If RANEXA is combined with other medications that increase the QT interval, this interaction may lead to a potentially fatal heart arrhythmia called Torsades de Pointes (TdP).

Side Effects

Some of the most common adverse reactions that occur when taking RANEXA include:

  • Abdominal pain
  • Bradycardia
  • Constipation
  • Dizziness
  • Dry mouth
  • Dyspnea
  • Headache
  • Hypotension
  • Nausea
  • Orthostatic hypotension
  • Palpitations
  • Peripheral edema
  • Tinnitus
  • Vertigo
  • Vomiting


  1. Ranexa [package insert]. Cincinnati, OH 45237: Pantheon; 2008.
  2. Healthline, What is Torsades de Pointes?, July 12th, 2017. Retrieved April 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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