Top Generic choice
Strength | Pack Size | Qty | |
---|---|---|---|
Strength
7.5mg
|
We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Primaquine phosphate is an oral antimalarial and tissue schizonticide indicated for the radical cure (relapse prevention) of Plasmodium vivax and Plasmodium ovale malaria, as well as the gametocidal treatment of Plasmodium falciparum to interrupt transmission. Primaquine acts by disrupting the mitochondrial electron transport chain in susceptible parasites, making it effective against the hypnozoite liver stage of P. vivax and P. ovale, which is not targeted by blood-stage antimalarials. It is typically used after completion of a standard course of blood schizonticidal treatment (e.g., chloroquine or artemisinin-based therapy).
Fact Table | |
Formula | C15H21N3O |
License | US FDA; WHO Essential Medicines |
Bioavailability | ~96% (oral) |
Legal status | Prescription only |
Chemical Name | 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinoline |
Elimination half-life | ~4–9 hours |
Dosage (Strength) | 7.5 mg, 15 mg, 26.3 mg tablets (as base or phosphate) |
Pregnancy | Contraindicated – risk of hemolysis in G6PD-deficient fetus |
Brands | Primaquine, generic versions globally |
Protein binding | ~20% |
PubChem CID | 4908 |
MedlinePlus | a682338 |
ChEBI | CHEBI:8677 |
ATC code | P01BA03 |
DrugBank | DB01087 |
KEGG | D08415 |
Routes of administration | Oral |
Primaquine is administered orally and should be taken with food to minimize gastrointestinal discomfort.
Dosage must be adjusted for body weight, age, and G6PD status. Treatment should not begin until glucose-6-phosphate dehydrogenase (G6PD) deficiency is ruled out.
Each tablet contains:
Inactive ingredients may include:
Primaquine is contraindicated in:
Screen for G6PD deficiency prior to starting therapy. Monitor patients for signs of hemolysis, particularly during the first week of therapy. Use with caution in patients with renal or hepatic impairment, and in those with methemoglobinemia, as primaquine may exacerbate oxidative stress. Concomitant use with other hemolytic agents (e.g., dapsone, sulfonamides) may increase risk of hematologic toxicity.
Common and potential side effects include: