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Prezcobix (Darunavir and Cobicistat)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Your doctor may have prescribed you Prezcobix if you have a chronic HIV infection. This drug contains a combination of active ingredients that helps prevent the progression of HIV infection.


Take this drug exactly as prescribed by your doctor. The standard dosage is one tablet by mouth once daily with food. 


The active ingredients are 800 mg of darunavir and 150 mg of cobicistat.

Darunavir works by shutting down protease proteins made by HIV viruses. 

Cobicistat does not affect HIV viruses directly but boosts the effects of darunavir.


Tell your doctor and pharmacist about all drugs you are taking before you start Prezcobix because it has many potential interactions. Examples include:

  • Acalabrutinib
  • Alfuzosin
  • Alprazolam
  • Aprepitant
  • Astemizole
  • Asunaprevir
  • Avanafil
  • Avapritinib
  • Barnidipine
  • Bilastine
  • Blonanserin
  • Bosentan
  • Bosutinib
  • Budesonide
  • Carbamazepine
  • Cisapride
  • Cobimetinib
  • Conivaptan
  • Dapoxetine
  • Daridorexant
  • Domperidone
  • Doxorubicin
  • Dronedarone
  • Elagolix
  • Elbasvir and Grazoprevir
  • Eletriptan
  • Eliglustat
  • Eplerenone
  • Ergot Derivatives
  • Everolimus
  • Finerenone
  • Flibanserin
  • Fluticasone
  • Fosamprenavir
  • Fosaprepitant
  • Fosphenytoin-Phenytoin
  • Fusidic Acid
  • Garlic
  • Glecaprevir and Pibrentasvir
  • Ibrutinib
  • Indinavir
  • Infigratinib
  • Isavuconazonium sulfate
  • Ivabradine
  • Lefamulin
  • Lemateperone
  • Lemborexant
  • Lercanidipine
  • Levoketoconazole
  • Lomitapide
  • Lonafarnib
  • Lopinavir
  • Lovastatin
  • Lurasidone
  • Lurbinectedin
  • Macitentan
  • Mequitazine
  • Midazolam
  • Mitapivat
  • Mobocertinib
  • Naloxegol
  • Neratinib
  • Nimodipine
  • Nisoldipine
  • Pacritinib
  • Pazopanib
  • Phenobarbital
  • Pimozide
  • Pralsetinib
  • Primidone
  • Protease inhibitors
  • Radotinib
  • Ranolazine
  • Red yeast rice
  • Regorafenib
  • Revefenacin
  • Rifampin
  • Rifapentine
  • Rimegepant
  • Ritonavir
  • Rivaroxaban
  • Rupatadine
  • Ruxolitinib
  • Salmeterol
  • Saquinavir
  • Silodosin
  • Simvastatin
  • Sirolimus
  • Sonidegib
  • St John's wort
  • Suvoraxant
  • Tamsulosin
  • Tazemetostat
  • Tepotinib
  • Terfenadine
  • Thioridazine
  • Ticagrelor
  • Tipranavir
  • Tolvaptan
  • Topotecan
  • Trabectedin
  • Triazolam
  • Ubrogepant
  • Udenafil
  • Vincristine
  • Vinflunine
  • Voclosporin
  • Vorapaxar
  • Voxilaprevir


Use caution if you have a history of kidney or liver dysfunction before starting this drug.

Tell your doctor if you have an allergy to sulfonamide medications before starting this drug.

Ask your doctor and pharmacist for a full list of precautions.

Side Effects

Common side effects include:

  • Abdominal pain
  • Diarrhea
  • Headache
  • Immune reconstitution syndrome
  • Nausea
  • Rash
  • Vomiting


Prezcobix. Titusville, NJ: Janssen Therapeutics; 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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