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Prempro (Estrogen/Medroxyprogesterone)

Also Known as Premia Continuous, Premique

Prescription medicineOnly Available By Prescription

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Chemical Name CONJUGATED ESTROGENS(ESS-troe-jenz) and MEDROXYPROGESTERONE (me-DROX-ee-proe-JESS-te-rone) Prempro is used to relieve the signs of menopause (such as hot flashes and unusual sweating, chills, faintness or dizziness), treat inflammation of the vagina and of the genital area, and to prevent the loss of bone that begins at the time of menopause. This medicine is an estrogen and progesterone combination used to treat the symptoms of menopause. It may also be used to treat certain menstrual disorders, osteoporosis, or other conditions as determined by your doctor. Alternative medicines to prevent bone loss (osteoporosis) include raloxifene and bisphosphonate drugs such as alendronate.

Fact Table




FDA approved


Estrogens: Variable; Medroxyprogesterone: Well absorbed

Legal status

Prescription only

Chemical Name


Elimination half-life

Estrogens: Variable; Medroxyprogesterone: Approximately 24-34 hours

Dosage (Strength)

Available in several strengths; common: 0.3 mg conjugated estrogens/1.5 mg medroxyprogesterone acetate

Pregnancy advice




Protein binding

Estrogens: Highly bound to serum proteins; Medroxyprogesterone: 90-95% bound

PubChem CID






ATC code

G03FA (Combinations of estrogens and progestogens)





Routes of administration



SIDE EFFECTS that may occur while taking this medication includes abdominal cramps, back pain, body aches or pain, breast pain or tenderness, diarrhea, dryness or soreness of throat, fever, flushing or redness of skin, general feeling of discomfort or illness, headache, severe throbbing, hoarseness, nausea, pain, passing of gas, shivering, shortness of breath or troubled breathing, sneezing, sore throat, stuffy nose, stomach discomfort following meals, unusual tiredness, and voice changes

Side Effects

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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