Premarin (Conjugated Estrogens)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Premarin (conjugated estrogens) is a medication used to treat many different conditions. The Premarin indications in the package insert include:

  • Moderate to severe vasomotor symptoms due to menopause
  • Moderate to severe symptoms of vulvar and vaginal atrophy due to menopause
  • Hypoestrogenism due to hypogonadism, castration, or primary ovarian failure
  • Breast cancer (palliation) in appropriately selected women and men with metastatic disease
  • Advanced androgen-dependent carcinoma of the prostate (palliation)
  • Prevention of postmenopausal osteoporosis

Premarin works by replenishing estrogen levels. Estrogen is a natural hormone that regulates a variety of bodily functions. During menopause, estrogen levels are reduced and replacing estrogen can help provide symptomatic relief of certain conditions. Increasing estrogen may also be used in the treatment of certain cancers and osteoporosis.

Fact Table







Legal status


Chemical Name

Conjugated estrogens

Elimination half-life

26.7 hours

Dosage (Strength)

0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg


Not Recommended



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth (Tablets)


The dosage of Premarin is dependent on the condition being treated. Take Premarin exactly as prescribed by your physician.

Premarin should be taken by mouth with or without food. It may be dosed every dose or may be dosed in cycles.


The active ingredients are conjugated equine estrogens.

Tablet strengths include:

  • Premarin 0.3 mg tablet
  • Premarin 0.45 mg tablet
  • Premarin 0.625 mg tablet
  • Premarin 0.9 mg tablet
  • Premarin 1.25 mg tablet


Premarin should be used in caution in those with a personal or family history of:

  • Angioedema
  • Cancers: breast cancer, endometrial cancer, ovarian cancer
  • Cardiovascular disorders: coronary heart disease, stroke, venous thromboembolism, 
  • Dementia
  • Endometriosis
  • Elevated blood pressure
  • Fluid retention
  • Gallbladder disease
  • Hepatic impairment
  • Hypercalcemia and hypocalcemia
  • Hypertriglyceridemia
  • Hypothyroidism
  • Vision abnormalities

Premarin can cause or worsen the above conditions. Speak to your doctor about your full medical history before starting Premarin.

Side Effects

Premarin has a wide range of possible side effects that can affect the following body systems:

  • Breasts
  • Cardiovascular system
  • Central nervous system
  • Eyes
  • Gastrointestinal system
  • Genitourinary system
  • Skin

Refer to the package insert and speak with your physician about all possible side effects. This is not a complete list.


  1. DailyMed "Premarin package insert." Published 2019. Accessed December 5, 2019.

Frequently Asked Questions about Premarin

What is Premarin used for?

Premarin tablets contain estrogen hormones. They help with menopause symptoms like hot flashes and vaginal changes. They also prevent bone loss and replace estrogen in women with low natural levels.

How long does Premarin stay in your system?

Duration varies. Ask your healthcare provider for personalized information.

Does Premarin cause weight gain?

Weight gain is uncommon with Premarin.

How long should a woman be on Premarin?

Use at the lowest effective dose for as long as needed. Discuss regularly with your healthcare provider.

Is Premarin just estrogen?

Yes, Premarin contains conjugated estrogens, which are forms of estrogen.

Is it safe to take Premarin long term?

Discuss long-term use with your healthcare provider considering risks and benefits.

What to avoid when taking Premarin?

Avoid if you have: certain health conditions such as undiagnosed vaginal bleeding, liver disease, bleeding disorder, history of heart attack, stroke, blood clot, or cancer of the breast, uterus/cervix, or vagina. Also, avoid if pregnant.

Who should not use Premarin?

Premarin should not be used if you have: undiagnosed vaginal bleeding, liver disease, bleeding disorder, history of heart attack, stroke, blood clot, or cancer of the breast, uterus/cervix, or vagina. Do not use it if you are pregnant.

When should Premarin be stopped?

Consult your healthcare provider for guidance on when to discontinue Premarin based on your individual needs and health status.

When is the best time of day to take Premarin?

Consistency is key; take it either in the morning or at night, but make sure to take it at the same time every day.

What are the side effects of Premarin estrogen pills?

Common side effects include stomach upset, nausea, vomiting, bloating, breast tenderness, or swelling.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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