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Pletal (Cilostazol)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Pletal (cilostazol) is a phosphodiesterase III inhibitor (PDE III inhibitor) used to improve the symptoms of intermittent claudication.

Pletal comes in 50 mg and 100 mg tablets.

Fact Table




US DailyMed



Legal status


Chemical Name


Elimination half-life

11–13 hours

Dosage (Strength)

50mg, 100mg





Protein binding


PubChem CID






ATC code






Routes of administration

By mouth (tablets)


The recommended dosage is 100 mg by mouth twice daily, 30 minutes before or two hours after breakfast and dinner.

The dose may be reduced to 50 mg by mouth twice daily when taken with ketoconazole, itraconazole, erythromycin, diltiazem, ticlopidine, fluconazole, and omeprazole. 


Cilostazol is the active ingredient in each tablet.


You should not take Pletal if you have heart failure.

Discuss your allergies with your doctor. You should not take Pletal if you are allergic to cilostazol or any of the other ingredients in Pletal as it can cause severe hypersensitivity reactions in those who are sensitive.



See full prescribing information for complete boxed warning.

PLETAL is contraindicated in patients with heart failure of any severity. Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with the pharmacologic effect have caused decreased survival compared to placebo patients with class III-IV heart failure. 

Tell your doctor if you have heart problems. Pletal can increase your heart rate or cause palpitations or low blood pressure.

Left ventricular outflow tract obstruction has been observed in some patients who were treated with Pletal. After starting Pletal, you should be monitored for a new murmur or heart symptoms.

Pletal can cause low blood counts.

Pletal can cause hemostatic disorders or bleeding. Pletal should be avoided in these patients.

Talk to your doctor about all the medications you take, including prescription and over-the-counter medications, vitamins, and supplements.

Let your doctor know if you are pregnant, think you are pregnant, or plan to become pregnant.

Let your doctor know if you are breastfeeding or plan to breastfeed.

Side Effects

Pletal can cause side effects such as:

  • Swelling of your legs or hands
  • Pharyngitis
  • Heart palpitations
  • Infection
  • Indigestion
  • Increased heart rate
  • Headache
  • Diarrhea
  • Dizziness

Contact your doctor right away if you experience any side effects while taking Pletal.


Pletal Rockville, MD: Otsuka America Pharmaceutical, Inc.; 2015.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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