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Pifeltro (Doravirine)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Pifeltro is an antiviral used to treat human immunodeficiency virus (HIV-1) infection in adults. Your doctor may prescribe this drug as part of a regimen if you have never received treatment before. It can also be used to replace the current regimen in people with suppressed viral load.

Pifeltro works by preventing the replication of HIV viral particles. Pifeltro works to slow and potentially suppress the ongoing infection by stopping viral replication.

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Routes of administration

By mouth


Take Pifeltro as part of a regimen for the treatment of HIV infection. Do not stop taking this drug without speaking with your doctor first.

The usual dosage is 100 mg by mouth once daily. The dose may be increased for people taking rifabutin to 100 mg twice daily.

This drug can be taken with or without food. 


The active ingredient in Pifeltro is doravirine.


Common drug-drug interactions with Pifeltro can include:

  • Apalutamide
  • Bexarotene
  • Bosentan
  • Carbamazepine
  • Cenobamate
  • Dabrafenib
  • Dexamethasone
  • Dipyrone
  • Efavirenz
  • Elagolix, estradiol, and norethindrone therapy pack?
  • Enzalutamide
  • Eslicarbazepine
  • Etravirine
  • Fosphenytoin
  • Lorlatinib
  • Lumacaftor
  • Mitapivat
  • Mitotane
  • Modafinil
  • Nafcillin
  • Pexidartinib
  • Phenobarbital
  • Phenytoin
  • Primidone
  • Rifabutin
  • Rifampin (rifampicin)
  • Rifapentine
  • Sotorasib
  • St. John's wort


Tell your doctor and pharmacist about all drugs you are taking before starting Pifeltro because it has many possible dangerous drug-drug interactions.

Your healthcare team should monitor for Immune Reconstitution Syndrome when you start taking this drug.

Side Effects

The most common Pifeltro side effects may include:

  • Abdominal pain
  • Abnormal dreams
  • Diarrhea
  • Dizziness
  • Fatigue
  • Headache
  • Increased LDL cholesterol
  • Increased serum alkaline phosphatase
  • Increased serum aspartate aminotransferase
  • Increased serum bilirubin
  • Increased serum creatine kinase
  • Increased serum creatinine
  • Increased serum lipase
  • Increased serum triglycerides
  • Insomnia
  • Nausea
  • Skin rash


Pifeltro. Whitehouse Station, NJ: Merck Sharp & Dohme Corp.; 2018.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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