Pennsaid (Diclofenac)

Description

Pennsaid (diclofenac sodium) topical solution 2% w/w, is a prescription nonsteroidal anti-inflammatory drug (NSAID) that is applied topically to treat knee osteoarthritis.

Pennsaid comes in a topical solution.

Diclofenac sodium is Pennsaid’s generic name.

Directions

Use Pennsaid as directed by the prescribing doctor, who will determine appropriate dosing for you.

Recommended dosing:

Apply 2 pumps on each painful knee two times a day; apply evenly around the front, back, and sides of the knee(s); ensure the skin is clean and dry before applying. Thoroughly wash your hands after use. Let the area completely dry before covering with clothing or applying sunscreen, insect repellant, cosmetics, or other topical products and medications. Avoid skin-to-skin contact until completely dried. Do not get the medication in your eyes, mouth, or nose.

Store Pennsaid at 25°C (77°F) and out of reach of children.

Refer to the information leaflet that accompanies your Pennsaid prescription for further instructions for use.

Contact your doctor or pharmacist about your questions or concerns.

Ingredients

Diclofenac sodium is the active ingredient in Pennsaid.

Dimethyl sulfoxide USP (DMSO, 45.5% w/w), ethanol, purified water, propylene glycol, and hydroxypropyl cellulose are the inactive ingredients included.

Contraindications

Pennsaid should not be used in patients who meet the following criteria:

• Are allergic to diclofenac or to any of its ingredients
• Have had asthma, hives, or allergic-type reactions from aspirin or other NSAIDs
• In the setting of coronary artery bypass graft (CABG) surgery

Cautions

• Pennsaid contains the following FDA Boxed Warning:
• An increased risk of heart attack, stroke, or other serious and potentially fatal cardiovascular thrombotic events with NSAID use. This risk may occur early in treatment and may become greater with duration of use
• Pennsaid use should be avoided in the setting of CABG surgery
• Increased risk of bleeding, ulceration, and perforation of the stomach or other potentially fatal gastrointestinal (GI) adverse effects with NSAID use. These events can occur at any time during use and without warning symptoms. Patients with a history of peptic ulcer disease and/or GI bleeding and elderly patients are at greater risk for these events
• Before you start using Pennsaid, discuss the following with your doctor:
• All the medications you use, including other topical products, prescription and nonprescription medications, vitamins, and supplements
• Any allergies you have
• Any Your current health problems you have
• Your past medical history
• If you are pregnant or breastfeeding
• Pennsaid contains the following warnings and precautions:
• Liver issues
• High blood pressure
• Heart failure and swelling
• Kidney issues
• Anaphylaxis
• Worsening of asthma due to aspirin sensitivity
• Skin reactions that are serious
• Drug reaction with eosinophilia and systemic symptoms (DRESS)
• Fetal harm; Women who are 30+ weeks pregnant should avoid NSAID use
• Anemia
• Avoid artificial or natural light exposure of the treated knee(s)
• Do not take other NSAIDs

Side Effects

Pennsaid side effects include but are not limited to application site reactions.

Call your doctor right away if you have bothersome or persistent side effects.

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Reference

Pennsaid. Deerfield, IL: Horizon Medicines LLC; 2022.

About Dr. Savannah Muncy (Page Author)

Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....