Also Known as FLEXADIN Plus
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Osteo-3 is a dietary supplement formulated to support bone health by combining three essential nutrients—calcium, vitamin D3, and vitamin K2—which work synergistically to promote bone mineralization, calcium absorption, and skeletal strength. It is commonly used as a preventive or adjunctive measure in individuals at risk for osteoporosis or with suboptimal bone density, including postmenopausal women, older adults, and individuals with limited sun exposure or dietary calcium intake. Osteo-3 is typically available in tablet or capsule form and is designed for daily use as part of a comprehensive bone health regimen.
| Fact Table | |
| Formula | CaCO3, C27H44O (Vitamin D3), C46H64O2 (Vitamin K2-7) |
| License | Dietary supplement (not FDA-approved as a drug) |
| Bioavailability | Varies by formulation (e.g., calcium citrate > calcium carbonate on empty stomach) |
| Legal status | OTC (Over-the-counter) |
| Chemical Name | Calcium carbonate, Cholecalciferol, Menaquinone-7 |
| Elimination half-life | Vitamin D3: ~15 days; Vitamin K2: ~72 hours |
| Dosage (Strength) | Calcium 500 mg, Vitamin D3 800 IU, Vitamin K2-7 90–120 mcg (per tablet/capsule) |
| Pregnancy | Generally considered safe in recommended doses |
| Brands | Osteo-3, Citracal, Caltrate, other multivitamin bone supplements |
| Protein binding | Vitamin D3: ~99%; Vitamin K2: high |
| PubChem CID | Calcium carbonate: 10112; Vitamin D3: 5280795; Vitamin K2-7: 5280537 |
| MedlinePlus | a682778 (Calcium); a682335 (Vitamin D) |
| ChEBI | Calcium carbonate: 3311; Vitamin D3: 28940; Vitamin K2: 74990 |
| ATC code | A12AX (calcium combos); A11CC05 (vitamin D) |
| DrugBank | Calcium carbonate: DB11093; Vitamin D3: DB00169; Vitamin K2: DB11783 |
| KEGG | Vitamin D3: D00094; Calcium carbonate: D00149 |
| Routes of administration | Oral |
The typical recommended dosage is one to two capsules daily, or as directed by a healthcare professional. Osteo-3 should be taken with meals to enhance absorption of fat-soluble vitamins (D3 and K2). For optimal effect, consistent daily use is recommended, and it may be used alongside exercise, weight-bearing activities, and other osteoporosis-prevention strategies.
Each serving of Osteo-3 may contain:
Calcium (as calcium citrate or carbonate) – 500–600 mg
Vitamin D3 (cholecalciferol) – 800–1000 IU (20–25 mcg)
Vitamin K2 (as menaquinone-7, MK-7) – 45–100 mcg
Inactive ingredients may include:
Cellulose, magnesium stearate, silica, and gelatin (for capsules)
Exact formulation can vary by manufacturer; verify label for specific contents.
Osteo-3 is contraindicated in individuals with:
Hypercalcemia or hypervitaminosis D
Known hypersensitivity to any of the ingredients
History of kidney stones (use caution with high-dose calcium supplementation)
Concurrent use of vitamin K antagonists (e.g., warfarin) unless under medical supervision
Use caution in patients with chronic kidney disease or conditions affecting calcium metabolism. Excessive intake of calcium or vitamin D can lead to hypercalcemia and associated complications. Patients taking anticoagulants should consult their healthcare provider before using supplements containing vitamin K2. Monitor total daily calcium intake from diet and other sources to avoid exceeding the recommended upper limit (~2000–2500 mg/day for adults). Pregnant and breastfeeding individuals should consult a healthcare provider prior to use.
Osteo-3 is generally well tolerated. Possible side effects include:
Mild gastrointestinal upset (bloating, constipation)
Nausea (especially with high doses or when taken on an empty stomach)
Hypercalcemia symptoms with excessive intake (e.g., fatigue, confusion, kidney dysfunction)
Rare: allergic reactions
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We pride ourselves on delivering excellent customer service with as much accessibility as possible.
If you have any questions at all, or would like to place an order, you are encouraged to contact us by toll-free
phone 1-888-904-8467 or email info@canadadrugsdirect.com.
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Canada Drugs Direct employs dedicated, professional licensed pharmacists to ensure that each and every order is reviewed before it is dispensed for the safety and health of our customers. At CanadaDrugsDirect.com, your health is our top priority.
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