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Osphena (Ospemifene)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Osphena is a prescription medication used to treat different symptoms of menopause, including dyspareunia (painful intercourse), and vulvar and vaginal atrophy. It can also be used to treat severe vaginal dryness.

Osphena works by binding to estrogen receptors and selectively activating some while blocking others. 

Menopause is a normal condition of aging that occurs when women are approximately aged 50 and up. Menopause is when the natural estrogen levels decrease, which causes symptoms like hot flashes, night sweats, and vaginal symptoms. Osphena works by activating different estrogen receptors in the body.

Fact Table







Legal status

Rx Only

Chemical Name


Elimination half-life


Dosage (Strength)



Consult Doctor


Osphena, Senshio

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


Take Osphena 60 mg tablet by mouth once daily. Take it exactly as prescribed by your doctor.


The active ingredient in Osphena is ospemifene


Common drug-drug interactions with this medication and others may include the following:

  • Abametapir
  • Apalutamide
  • Fexinidazole
  • Fluconazole
  • Fusidic Acid (Systemic)
  • Selective Estrogen Receptor Modulators
  • Atazanavir
  • Ceritinib
  • Clarithromycin
  • Cobicistat and cobicistat-containing coformulations
  • Darunavir
  • Fluoroestradiol F18
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Levoketoconazole
  • Lonafarnib
  • Lopinavir
  • Mifepristone
  • Nefazodone
  • Nelfinavir
  • Ombitasvir-paritaprevir-ritonavir
  • Ombitasvir-paritaprevir-ritonavir plus dasabuvir
  • Posaconazole
  • Ritonavir and ritonavir-containing formulations
  • Saquinavir
  • Telithromycin
  • Tucatinib
  • Voriconazole

If you have any questions about drug-drug interactions, please contact your pharmacist and doctor.


Do not use this medication if you have a history of abnormal genital bleedings.

Tell your doctor if you have a history of clotting disorders like heart attack, pulmonary embolism, or deep vein thrombosis.

Do not use this medication if you suspect you are pregnant or could become pregnant.

Side Effects

Common Osphena side effects can include:

  • Angioedema
  • Cerebrovascular accident
  • Cyst
  • Deep vein thrombosis
  • Endometrial carcinoma
  • Endometrial hyperplasia
  • Endometrial polyps
  • Erythematous rash
  • Headache
  • Hot flash
  • Hyperhidrosis
  • Hypersensitivity reaction
  • Malignant neoplasm
  • Myocardial infarction
  • Night Sweats
  • Pruritus
  • Pulmonary embolism
  • Vaginal discharge
  • Vaginal hemorrhage


Osphena. Florham Park, NJ: Shionogi Inc; 1/2019.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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