Oseni (Alogliptin/pioglitazone)

Prescription medicineOnly Available By Prescription
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Strength
12.5mg/15mg
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25mg/15mg
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12.5mg/30mg
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Strength
25mg/30mg
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Strength
12.5mg/45mg
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Strength
25mg/45mg
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Top Generic choice

Strength Pack Size Qty
Strength
12.5mg/15mg
Pack Size
Qty
Strength
25mg/15mg
Pack Size
Qty
Strength
12.5mg/30mg
Pack Size
Qty
Strength
25mg/30mg
Pack Size
Qty
Strength
12.5mg/45mg
Pack Size
Qty
Strength
25mg/45mg
Pack Size
Qty

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Oseni (alogliptin and pioglitazone) is a drug that is used with diet and exercise to help improve type 2 diabetes in adults.


Fact Table

Formula

C18H21N5O2, C19H20N2O3S

License

US DailyMed, US FDA, EU EMA

Bioavailability

100%

Legal status

Rx-Only

Chemical Name

Alogliptin/pioglitazone

Elimination half-life

3–21 hours

Dosage (Strength)

12.5mg/45mg, 12.5mg/15mg, 25mg/15mg, 12.5mg/30 mg, 25mg/30mg, 25mg/45mg

Pregnancy

Consult Doctor

Brands

Oseni

Protein binding

20%

PubChem CID

11450633, 4829

MedlinePlus

a613026, a699016

ChEBI

72323, 8228

ATC code

A10BH04, A10BG03

DrugBank

DB11827, DB01261

KEGG

DB01132

Routes of administration

By mouth

Directions

Oseni is available as a tablet in various strengths:

12.5 mg alogliptin/15 mg pioglitazone, 12.5 mg/30 mg pioglitazone, 12.5 mg alogliptin/45 mg pioglitazone

25 mg alogliptin/15 mg pioglitazone, 25 mg alogliptin/30 mg pioglitazone, 25 mg alogliptin/45 mg pioglitazone 

Your initial dose will be based on your current treatment and medical condition(s) and should not be more than alogliptin 25 mg/pioglitazone 45 mg per day. 

You may be instructed to take a lower dose if you have heart failure, kidney problems, or if you take certain medications such as gemfibrozil.

Oseni may be taken with or without food. 

Ingredients

Alogliptin and pioglitazone are the active ingredients contained in Oseni.

Contraindications

Talk to your doctor about your allergies. You should not take Oseni if you are allergic to alogliptin, pioglitazone, or any of the other ingredients in Oseni.

You should not take Oseni if you have been diagnosed with NYHA Class III or IV heart failure.

Cautions

WARNING: CONGESTIVE HEART FAILURE

See full prescribing information for complete boxed warning

  • Thiazolidinediones, including pioglitazone, cause or
    exacerbate congestive heart failure in some patients. 
  • After initiation of OSENI and after dose increases, monitor
    patients carefully for signs and symptoms of heart failure (e.g., excessive, rapid weight gain, dyspnea, and/or edema). If heart failure develops, it should be managed according to current standards of care and discontinuation or dose reduction of pioglitazone in OSENI must be considered.
  • OSENI is not recommended in patients with symptomatic heart failure.
  • Initiation of OSENI in patients with established New York Heart Association (NYHA) Class III or IV heart failure is contraindicated. 
  • Before you start Oseni, tell your doctor:
    • About any medications you take, including prescription, non-prescription, vitamins, and herbal supplements
    • About any of your medical conditions
    • If you are pregnant or plan to become pregnant
    • If you are breastfeeding or plan to breastfeed
  • Congestive heart failure may worsen or occur with the use of Oseni. Contact your doctor right away if you experience trouble breathing with activity or when lying down, fatigue, weakness, swelling in the abdomen, legs, ankles, and feet, abnormal heart beat, a cough that won't go away, rapid weight gain, nausea, no appetite, problems concentrating, or chest pain. 
  • Acute pancreatitis can occur with the use of Oseni. Seek care right away if you experience abdominal pain, pain that radiates from your abdomen to your back, tenderness of the abdomen, fever, fast pulse, nausea, and vomiting.
  • Liver problems can occur with the use of Oseni and can be fatal. 
  • Swelling can occur with the use of Oseni.
  • Fractures can occur in female patients who take Oseni.
  • Bladder cancer can occur with the use of Oseni. Caution should be used if you have ever had bladder cancer. You should not take Oseni if you have active bladder cancer. 
  • You may experience low blood sugar if you take Oseni with insulin or other medications that can also lower your blood sugar. Watch for signs of low blood sugar. Treat your low blood sugar as your doctor has instructed.
  • Tell your doctor if you develop vision changes. 

Side Effects

Common cold, back pain, and upper respiratory tract infection are the most common side effects of Oseni. Tell your doctor right away if you develop side effects that are bothersome or won't go away.

References:

  1. Oseni Prescribing Information. Deerfield, IL: Takeda Pharmaceuticals America Inc.; 2013.
  2. Heart failure. Mayo Clinic. December 10, 2021. Accessed February 4, 2022.
  3. Pancreatitis. Mayo Clinic. September 24, 2021. Accessed February 4, 2022.


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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