Orilissa (Elagolix)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Orilissa (Elagolix) is a medication used to manage moderate to severe pain caused by endometriosis. It is a nonpeptide small molecule that works as a gonadotropin-releasing hormone (GnRH) receptor antagonist. By blocking GnRH receptors, it reduces the levels of hormones like estrogen, which contributes to endometriosis pain.


The typical dosage for managing endometriosis pain varies based on the severity of symptoms.

  • Standard dosages:
    • 150 mg: Once daily.
    • 200 mg: Twice daily.

Take the medication at the same time each day, with or without food. Tablets should be swallowed whole with water. Never change the dose or frequency without consulting a healthcare provider. It’s important to start with the lowest effective dose tailored to individual needs to reduce potential side effects.


The active ingredient in Orilissa is Elagolix.


Orilissa may not be suitable for everyone. You should avoid taking or using this medication if any of the following apply:

  • Currently pregnant
  • Known osteoporosis
  • Severe liver impairment
  • Taking organic anion transporting polypeptide (OATP) 1B1 inhibitors
  • Hypersensitivity to Elagolix or any of the ingredients


  • Before using Orilissa, ensure you provide your healthcare provider with the following information:
    • Existing health conditions
    • Known allergies
    • A list of all the medications you are currently taking
    • Your pregnancy or breastfeeding status
  • Orilissa can lead to a decrease in bone density, which might not fully reverse after stopping treatment. This is more likely with longer use or higher doses. Bone density should be monitored if you have risk factors for osteoporosis.
  • Orilissa can alter menstrual bleeding, possibly changing your ability to recognize pregnancy. If you suspect you are pregnant, get a pregnancy test. Discontinue Orilissa if pregnancy is confirmed.
  • Watch for any signs of worsening depression, anxiety, or mood changes, including thoughts of suicide. It's important to seek medical attention if you experience these mental health changes.
  • Orilissa has been linked to increases in liver enzymes, which can indicate liver damage. Be vigilant for symptoms such as yellowing of the skin or eyes, dark urine, or pain in your abdomen's upper right side.
  • Avoid hormonal contraceptives during and for 28 days after Orilissa treatment, as it can decrease their effectiveness and heighten the risk of estrogenic side effects. Use non-hormonal forms of contraception instead.

Side Effects

Orilissa may cause several side effects. These include hot flashes, night sweats, headaches, nausea, and difficulty sleeping. Individuals might also experience menstrual irregularities, anxiety, joint pain, depression, and other mood changes.

Other concerns with Orilissa involve potential mental health changes. It may cause or worsen depression and anxiety, and in severe cases, lead to suicidal thoughts or behaviors. Immediate medical attention is necessary if you notice abrupt or serious changes in your mood or behavior. Orilissa can also affec liver function, signs of which include yellowing of the skin or eyes, dark urine, extreme fatigue, nausea, swelling, pain in the upper right abdomen, or easy bruising. Alert your healthcare provider promptly if these symptoms develop.


  1. Orilissa (Elagolix) Product Monograph. North Chicago, IL: AbbVie Inc.; 2023.
  2. Orilissa (Elagolix) Drug Label Information. North Chicago, IL: AbbVie Inc.; 2023.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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