Onzetra Xsail (Sumatriptan nasal powder)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
11mg 16 Nosepieces
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Your healthcare provider may have prescribed Onzetra Xsail to treat migraine headaches. This medication is an important drug that can stop a migraine headache if used correctly. Migraine headaches are one of the many symptoms of a migraine and can be extremely painful and debilitating.

Onzetra Xsail works by activating serotonin receptors in the brain. Activating serotonin receptors does a few things to stop migraine headaches, including relaxing the brain's blood vessels and reducing inflammation.

Fact Table






15% - 96%

Legal status

US: RX Only

Chemical Name


Elimination half-life

2.5 hours

Dosage (Strength)



Consult Doctor


Onzetra Xsail , Imitrex, Imigran

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth, subcutaneous injection, nasal spray, transdermal electrophoresis


Inhale the contents of one capsule, 11 mg, into each nostril at the onset of migraine symptoms. Consult the package insert for directions on how to use the device.

Onzetra Xsail should not be used more than twice in 24 hours.


The active ingredient in Onzetra Xsail is sumatriptan.


Tell your doctor about any medications you take before you start Onzetra Xsail. Tell your doctor and pharmacist if you are taking the following medicines:

  • Bromocriptine
  • Buspirone
  • Citalopram
  • Clomipramine
  • Dextromethorphan
  • Dihydroergotamine 
  • Droxidopa
  • Ergotamine 
  • Escitalopram
  • Fluoxetine
  • Fluvoxamine
  • Imipramine
  • Mirtazapine
  • Monoamine Oxidase Inhibitors
  • Paroxetine
  • Sertraline
  • Trazodone
  • Venlafaxine


Do not use Onzetra Xsail more frequently than twice in 24 hours because tolerance can develop to the effects of the medication. The maximum dose in 24 hours is 44 mg.

Tell your doctor if you have a history of heart or liver problems before taking this drug.

Use caution if you are taking serotonergic drugs or ergot derivatives before starting this medication.

Side Effects

Common adverse reactions to this drug can include:

  • Dizziness
  • Dysgeusia 
  • Local irritation
  • Localized burning
  • Localized numbness
  • Nasal cavity pain
  • Nasal discomfort
  • Nausea
  • Paresthesia
  • Rhinitis
  • Rhinorrhea
  • Sinus discomfort
  • Sore nose
  • Unusual taste
  • Vertigo
  • Vomiting

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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