Ongentys (Opicapone)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Ongentys (opicapone) is used with levodopa/carbidopa to treat "off" episodes in patients with Parkinson's Disease.


When you receive your Ongentys prescription, be sure to follow the instructions that come with it. Talk to your doctor or pharmacist about any questions or concerns you may have.

Ongentys is supplied in oral capsules of 25 mg and 50 mg strengths.

Recommended dose: Take 50 mg by mouth one time a day at bedtime. Do not eat food for at least 1 hour before and 1 hour after taking Ongentys. Your doctor may prescribe a lower dose if you have liver problems. Ongentys should be avoided if you have severe liver problems.


Opicapone, a selective and reversible catechol-O-methyltransferase (COMT) inhibitor, is the active ingredient contained in each Ongentys capsule.


Avoid taking Ongentys with non-selective monoamine oxidase (MAO) inhibitors. If you are not sure whether or not you take MAO inhibitors, ask your doctor.

Avoid taking Ongentys if you have ever had pheochromocytoma, paraganglioma, or other catecholamine-secreting tumors.


  • Before you start taking Ongentys, inform your doctor:
    • Of all the prescription and nonprescription medications you take. These include vitamins and herbal supplements.
    • Of your allergies.
    • Of your medical conditions.
    • Of your pregnancy status. Ongentys may cause harm to an unborn baby.
    • Of your breastfeeding status. It has not been determined whether or not Ongentys can be passed into breast milk. 
  • If you have end-stage kidney disease, avoid taking Ongentys.
  • An elevated heart rate, arrhythmias, and major blood pressure changes can occur with the use of Ongentys. If you experience any of these effects, get medical care immediately. 
  • Drowsiness or falling asleep can occur, even during the daytime, with the use of Ongentys. Do not drive or operate machinery until you know how the medication affects you.
  • Low blood pressure can occur with the use of Ongentys. You should monitor your blood pressure during treatment with Ongentys.
  • Dyskinesia, or sudden involuntary movements, may occur or worsen with the use of Ongentys. If this occurs, contact your doctor immediately.
  • Hallucinations or psychosis can occur with the use of Ongentys. If you experience these effects, contact your doctor immediately.
  • Impulsive behaviors or intense and uncontrollable urges to gamble, spend money, binge eat, and/or other urges can occur with the use of Ongentys. If you experience any of these effects, contact your doctor immediately.
  • Withdrawal-emergent hyperpyrexia and confusion with symptoms that can include a fever, stiff muscles, altered mental status, and autonomic instability may occur if Ongentys is suddenly stopped or the dose is suddenly decreased. Ongentys doses should be tapered. If being discontinued, Ongentys should be gradually withdrawn.

Side Effects

The most common side effects of Ongentys include constipation, low blood pressure, elevated blood creatine kinase, weight loss, and sudden and involuntary movements. These are not all the possible side effects of Ongentys. Contact your doctor right immediately if you experience side effects that concern you or persist.


  1. Ongentys (opicapone) capsules, for oral use. San Diego, CA: Neurocrine Biosciences, Inc.; 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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