Omvoh (Mirikizumab)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Omvoh (mirikizumab-mrkz) is a humanized IgG4 monoclonal antibody that selectively targets interleukin-23 (IL-23) by binding to its p19 subunit. It is indicated for the treatment of adults with moderately to severely active ulcerative colitis (UC) who have had an inadequate response, lost response, or were intolerant to conventional therapy or biologics. By inhibiting IL-23, Omvoh reduces inflammation and promotes mucosal healing in the colon. It is the first IL-23p19 inhibitor approved for ulcerative colitis and provides a targeted immunomodulatory approach with both induction and maintenance treatment phases.

Fact Table

Formula

Not applicable (monoclonal antibody)

License

US FDA (2023)

Bioavailability

~55% (subcutaneous)

Legal status

Prescription only

Chemical Name

Mirikizumab

Elimination half-life

~10.7 days

Dosage (Strength)

300 mg IV (induction); 200 mg SC every 4 weeks (maintenance)

Pregnancy

Use only if benefits outweigh risks; no adequate human data

Brands

Omvoh

Protein binding

Not applicable (IgG4 monoclonal antibody)

PubChem CID

123823600

MedlinePlus

a622036

ChEBI

N/A

ATC code

L04AC24

DrugBank

DB15090

KEGG

D12430

Routes of administration

Intravenous (IV), Subcutaneous (SC)

Directions

Omvoh is administered in two phases:

  • Induction phase: 300 mg intravenous infusion every 4 weeks for a total of three doses (weeks 0, 4, and 8).
  • Maintenance phase: Beginning at week 12, patients who achieve clinical response should receive 200 mg subcutaneously every 4 weeks.

Infusions must be given by a healthcare professional. Subcutaneous doses may be administered by a healthcare provider or self-injected after proper training. Clinical response should be assessed periodically to determine continued treatment benefit.

Ingredients

Each mL of Omvoh contains:

  • Mirikizumab-mrkz (concentration varies by formulation: 300 mg/15 mL for IV; 200 mg/1 mL for SC)

Inactive ingredients include:

  • Sucrose, histidine, polysorbate 80, and water for injection

Omvoh is preservative-free and must be stored refrigerated at 2°C to 8°C. Do not freeze or shake.

Contraindications

Omvoh is contraindicated in patients with:

  • Known hypersensitivity to mirikizumab or any component of the formulation
  • Clinically significant active infections, particularly untreated tuberculosis

Cautions

Omvoh may increase the risk of infections, including upper respiratory tract infections and tuberculosis. Patients should be screened for latent TB prior to initiating therapy and monitored during treatment. Live vaccines should be avoided during treatment. As with other immunomodulators, caution is advised in patients with a history of chronic or recurrent infections, malignancy, or demyelinating disease. If a serious infection develops, Omvoh should be discontinued until resolution. Safety in pregnancy and breastfeeding has not been fully established; use only if benefits outweigh potential risks.

Side Effects

Common and potential side effects include:

  • Upper respiratory tract infections
  • Injection site reactions
  • Headache
  • Arthralgia
  • Rash
  • Fatigue
  • Rare: serious hypersensitivity reactions, including anaphylaxis; serious infections

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

product reviews icon Product Reviews