Ofev (Nintedanib)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Ofev is a prescription medication given for the treatment of:

  • Idiopathic pulmonary fibrosis
  • Chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype

It can also be given to slow the rate of pulmonary function decline in those with systemic

sclerosis-associated interstitial lung disease (SSc-ILD).

Ofev is most commonly prescribed by a lung specialist called a pulmonologist.

Ofev is a tyrosine kinase receptor inhibitor. It works by shutting down multiple signal pathways that are associated with lung disease.

Fact Table







Legal status


Chemical Name


Elimination half-life

10–15 hrs

Dosage (Strength)

100mg, 150mg


Consult Doctor


Vargatef, Ofev

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


The usual Ofev dosing is 150 mg by mouth with food twice per day. 

The doctor may lower the dose to 100 mg twice daily for people who get side effects while taking Ofev. The lower dosage should also be used for people with liver impairment.


The active ingredient in Ofev is nintedanib.


Ofev has drug-drug interactions with many different medications. Tell your doctor or pharmacist if you are taking:

  • Anticoagulants
  • Apalutamide
  • Atazanavir
  • Carbamazepine
  • Ceritinib
  • Clarithromycin
  • Cobicistat and cobicistat-containing coformulations
  • Darunavir
  • Enzalutamide
  • Fosphenytoin
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Lonafarnib
  • Lopinavir
  • Lumacaftor
  • Lumacaftor-ivacaftor
  • Mifepristone
  • Mitotane
  • Nefazodone
  • Nelfinavir
  • Ombitasvir-paritaprevir-ritonavir
  • Ombitasvir-paritaprevir-ritonavir plus dasabuvir
  • Phenobarbital
  • Phenytoin
  • Posaconazole
  • Primidone
  • Rifampin (rifampicin)
  • Ritonavir and ritonavir-containing coformulations
  • Saquinavir
  • Telithromycin
  • Tobacco
  • Tucatinib
  • Voriconazole

This is not a complete list of drug-drug interactions with Ofev. Speak with your doctor or pharmacist whenever you started Ofev or a new medication.


Your doctor will test your liver enzymes before starting this medication. Tell your doctor if you have a history of liver disease.

Ofev is toxic to a developing embryo, and the doctor will administer a pregnancy test to females of reproductive age before starting this medication.

Use caution if you have a history of gastrointestinal surgeries or gastrointestinal conditions.

Ofev can increase the risk of thromboembolism (clot) and bleed in certain people.

Side Effects

  • Abdominal pain
  • Decreased appetite
  • Decreased weight
  • Diarrhea
  • Headache
  • Hypertension
  • Liver enzyme elevation
  • Nausea


  1. Ofev [package insert].Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc; 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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