Oesclim (Estradiol)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Oesclim is a transdermal hormone replacement therapy (HRT) patch that delivers estradiol, the primary estrogen produced by the ovaries. It is indicated for the treatment of moderate to severe vasomotor symptoms (such as hot flushes) associated with menopause, as well as for the prevention of postmenopausal osteoporosis in women at significant risk who are unable to use non-estrogenic medications. By supplementing endogenous estrogen levels, Oesclim helps alleviate menopausal symptoms and supports bone density maintenance in estrogen-deficient postmenopausal women.

Fact Table

Formula

C18H24O2

License

EMA, US FDA

Bioavailability

Transdermal: ~20%

Legal status

Prescription only (Rx-only)

Chemical Name

Estradiol

Elimination half-life

13–20 hours (transdermal)

Dosage (Strength)

25 µg/day, 37.5 µg/day, 50 µg/day, 75 µg/day, 100 µg/day (transdermal patches)

Pregnancy

Contraindicated

Brands

Oesclim, Estraderm, Vivelle-Dot, Climara, Alora

Protein binding

98%

PubChem CID

5757

MedlinePlus

a605032

ChEBI

16469

ATC code

G03CA03

DrugBank

DB00783

KEGG

D00105

Routes of administration

Transdermal, Oral, Intramuscular, Vaginal

Directions

Oesclim is applied once weekly or twice weekly, depending on the prescribed regimen, typically using patches of 25 to 100 micrograms of estradiol delivered per 24 hours. The patch should be applied to a clean, dry, and hairless area of the lower abdomen or buttocks, avoiding the breasts. The application site should be rotated with each new patch to minimize skin irritation. Continuous or cyclical regimens may be used depending on whether the woman has an intact uterus and whether progestogen is co-administered. In women with a uterus, a progestogen should be added to reduce the risk of endometrial hyperplasia.

Ingredients

Each Oesclim patch contains synthetic 17ß-estradiol in varying strengths (e.g., 25, 50, 75, or 100 micrograms per 24 hours), delivered via an acrylate-based adhesive matrix. Inactive components include acrylic copolymer, oleyl alcohol, and a polyester release liner.

Contraindications

Oesclim is contraindicated in women with a history or presence of estrogen-dependent malignancies (e.g., breast or endometrial cancer), undiagnosed abnormal genital bleeding, active or past thromboembolic disease (e.g., deep vein thrombosis, pulmonary embolism), known thrombophilic disorders, active or recent arterial thromboembolic disease (e.g., stroke, myocardial infarction), liver dysfunction or disease, and known hypersensitivity to estradiol or any patch components.

Cautions

Use with caution in women with risk factors for cardiovascular disease, thromboembolic disorders, or hormone-sensitive malignancies. Estrogen therapy may increase the risk of endometrial cancer when used without a progestogen in women with an intact uterus. Long-term use is associated with increased risks of breast cancer, stroke, and venous thromboembolism. Regular clinical evaluations, including breast and pelvic exams, are advised. HRT should be used at the lowest effective dose for the shortest duration consistent with treatment goals. Periodic reassessment of the need for continued therapy is essential.

Side Effects

Common and serious side effects associated with Oesclim include:

  • Skin irritation at the application site
  • Breast tenderness or pain
  • Nausea
  • Headache
  • Fluid retention
  • Mood changes
  • Vaginal bleeding or spotting
  • Increased risk of venous thromboembolism (VTE)
  • Stroke and myocardial infarction (especially in older women)
  • Increased risk of breast and endometrial cancer with prolonged use

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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