Odefsey (Emtricitabine / Rilpivirine / Tenofovir Alafenamide)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Odefsey (emtricitabine, rilpivirine, tenofovir alafenamide) is used to treat human immunodeficiency virus-1 (HIV-1) infection in adults and children who weigh 77 pounds (35 kg) or more:

  • who have not received prior HIV-1 therapy and who have less than or equal to 100,000 copies/mL HIV-1 in the blood, or
  • to replace their current HIV-1 medications in those who meet certain requirements as deemed by their doctor

Odefsey is a combination drug of 200 mg of emtricitabine, 25 mg of rilpivirine, and 25 mg of tenofovir alafenamide.


Take one tablet by mouth once daily with a meal.


Emtricitabine, rilpivirine, and tenofovir alafenamide are the active ingredients in each tablet. 


Do not take Odefsey with drugs that can decrease rilpivirine plasma concentrations.



See full prescribing information for complete boxed warning.

Severe acute exacerbations of hepatitis B have been reported in patients who are coinfected with HIV-1 and HBV and have discontinued products containing emtricitabine (FTC) and/or tenofovir disoproxil fumarate (TDF), and may occur with discontinuation of ODEFSEY. Hepatic function should be monitored closely in these patients. If appropriate, anti-hepatitis B therapy may be warranted. 

Discuss your allergies with your doctor. Skin and hypersensitivity reactions can occur in patients who are allergic to Odefsey (emtricitabine, rilpivirine, tenofovir alafenamide) or any of the ingredients.

Tell your doctor about any medications you take, including over-the-counter medications. Odefsey may interact with certain medications, leading to potentially dangerous reactions.

Odefsey can cause damage to the liver. Liver enzymes should be monitored.

Depression or mood changes have happened with Odefsey. Tell your doctor right away if you feel sad, hopeless, or anxious or if you have suicidal thoughts or ideations.

Odefsey can cause kidney impairment or worsen kidney function. Kidney function and labs should be monitored.

The risk of Torsade de Pointes is increased with the use of Odefsey and other medications that can cause QT prolongation.

Odefsey may cause lactic acidosis or liver enlargement. Your doctor may discontinue Odefsey if you develop symptoms or have lab findings of lactic acidosis or liver damage.

Changes in your immune system may occur with the use of Odefsey.

Let your doctor know if you are pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed.

Side Effects

The most common side effects of Odefsey include:

  • Headache
  • Sleep problems

These may not be all of the possible side effects. Tell your doctor right away if you experience side effects that are bothersome or won't go away.


  1. Odefsey (emtricitabine, rilpivirine, tenofovir alafenamide). Foster City, CA: Gilead Sciences, Inc.; 2021. 
  2. Odefsey (emtricitabine, rilpivirine, tenofovir alafenamide).Foster City, CA: Gilead Sciences, Inc.; 2021. 

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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