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Nocdurna (Desmopressin)

Prescription medicineOnly Available By Prescription

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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Nocdurna (desmopressin acetate) is a prescription medication used for treating nighttime urination due to nocturnal polyuria in adults who wake up at least two times during the night to urinate.

Nocdurna is available in 27.7 mcg and 55.3 mcg tablets; these tablets are to be placed underneath the tongue to dissolve.

Fact Table






Variable; 0.08–0.16% (by mouth)

Legal status


Chemical Name


Elimination half-life

1.5–2.5 hours

Dosage (Strength)

25mcg, 50mcg


Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration

Sublingually as tablets


Nocdurna should be taken as your doctor has advised. If you have any questions or concerns, talk to your doctor or pharmacist.

Dosage for women:

One 27.7 mcg tablet should be placed underneath the tongue one time per day without water. Administer one hour before bedtime.

Dosage for men:

One 55.3 mcg tablet should be placed underneath the tongue one time per day without water. Administer one hour before bedtime.


Desmopressin acetate is the active ingredient in Nocdurna. Gelatin, NF (fish source), mannitol, and anhydrous citric acid are the inactive ingredients included.


Avoid taking Nocdurna if you have:

  • Low sodium levels or a history of low sodium levels
  • Excess thirst
  • Kidney conditions
  • Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
  • An illness that can cause fluid or electrolyte imbalances
  • Heart failure
  • Uncontrolled high blood pressure

Also, avoid taking the medication if you are taking loop diuretics or systemic or inhaled glucocorticoids.


The following FDA Boxed Warnings are associated with Nocdurna:

  • Nocdurna can cause low sodium levels that can be life-threatening
  • Nocdurna should not be administered to patients at risk of severe low sodium levels, such as in patients with excessive fluid intake, illnesses that can cause fluid or electrolyte imbalances, and in those taking loop diuretics or systemic or inhaled glucocorticoids
  • Blood sodium levels should be normal before starting or resuming Nocdurna. Blood sodium should be measured within 1 week and about 1 month after starting Nocdurna and periodically during treatment. More frequent monitoring should be performed in patients who are at least 65 years of age and in patients who are at increased risk for low sodium levels.
  • If a patient develops low sodium levels, Nocdurna may need to be stopped temporarily or permanently.
  • Before you begin treatment with Nocdurna, talk to your doctor about:
    • All prescription and nonprescription medications you take
    • Any allergies you may have
    • Your past medical history and current health issues
    • Your pregnancy status
    • Your breastfeeding status
  • It is recommended to limit fluid consumption from 1 hour prior to, or until 8 hours after, taking Nocdurna.
  • Nocdurna is not recommended in patients who are at risk of increased intracranial pressure or have a history of urinary retention.

Side Effects

Some, but not all, Nocdurna side effects include dry mouth, decreased blood sodium levels, and dizziness. Immediately talk to your doctor if you develop bothersome or persistent side effects.

Looking to buy Nocdurna online at a competitive price? With a valid prescription from your doctor, you can find a competitive Nocdurna cost at Canada Drugs Direct.


  1. Nocdurna. Ewing, NJ: Antares Pharma Inc.; 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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