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Nitro-Dur (Nitroglycerin Transdermal)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
0.4mg
Pack Size
Qty
Strength
0.6mg
Pack Size
Qty
Strength
0.8mg
Pack Size
Qty

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Nitro-Dur (Nitroglycerin Transdermal) is a transdermal patch used to prevent angina pectoris, a type of chest pain caused by coronary artery disease. This drug is classified as an organic nitrate and acts as a vasodilator, expanding both arteries and veins to boost blood flow. Nitro-Dur works by releasing nitroglycerin through the skin, gradually decreasing the occurrence and severity of angina attacks. This medication is not used to treat sudden chest pain episodes but rather serves as a preventative measure for individuals with coronary artery disease.

Fact Table

Formula

C3H5N3O9

License

US FDA, US DailyMed, EU EMA

Bioavailability

Less than 1%

Legal status

Rx-Only

Chemical Name

Nitroglycerin Transdermal

Elimination half-life

1 to 4 minutes

Dosage (Strength)

0.4mg, 0.6mg, 0.8mg

Pregnancy

Consult a healthcare provider for advice

Brands

Nitro-Dur

Protein binding

Minimal

PubChem CID

4510

MedlinePlus

a601086

ChEBI

28787

ATC code

C01DA02

DrugBank

DB00727

KEGG

D00515

Routes of administration

Transdermal

Directions

Nitro-Dur is administered through a transdermal patch applied directly to the skin. Use the medicine as directed by your doctor, without altering the dosage, frequency, or duration of use. When applying the patch, select a clean, dry, and hairless area of the skin, preferably on the chest or upper arm. The patch should be applied at the same time every day and replaced after 12 to 14 hours to allow for a nitrate-free interval, which helps prevent nitrate tolerance.

Ingredients

The active ingredient in Nitro-Dur is Nitroglycerin. Nitroglycerin is combined with acrylic-based polymer adhesives and a resinous cross-linking agent to create the transdermal system.

Contraindications

Avoid using this medication if any of the following apply:

  • You have experienced an allergic reaction to Nitroglycerin or adhesive in the past.
  • You are taking medications for erectile dysfunction, such as avanafil, sildenafil, tadalafil, or vardenafil
  • You are using pulmonary hypertension medications, like riociguat

Cautions

  • When using Nitro-Dur, there are certain precautions that must be taken to ensure safe and effective use. Tell your healthcare provider about the following:
    • Other medications you take.
    • Other medical conditions you have.
    • Whether you are pregnant or breastfeeding.
  • The combination of Nitro-Dur with phosphodiesterase inhibitors may cause low blood pressure. While the specifics of this interaction are not fully understood, treating it as an overdose may be recommended.
  • The application of Nitro-Dur in cases of heart attacks or heart failure has not been thoroughly established. Your doctor may need to watch your health closely to avoid problems like dangerously low blood pressure or fast heartbeat.
  • The placement of a cardioverter/defibrillator electrode directly over a Nitro-Dur patch should be avoided. It can cause harmless sparks, but it can lead to damage to the equipment and burns on the skin.
  • Nitro-Dur should be used cautiously, especially in the elderly or those who may be volume-depleted, on multiple medications, or already hypotensive. Even small doses of nitroglycerin can cause severely low blood pressure, which may be accompanied by a paradoxical slow heartbeat and increased chest pain.
  • Older adults should be cautious with Nitro-Dur as they may be more prone to the effects of low blood pressure and could have a higher chance of falling.
  • In people with a certain type of chest pain caused by a thickened heart muscle, known as hypertrophic cardiomyopathy, Nitro-Dur might actually make things worse.
  • People who have worked with nitrates over a long period can develop a tolerance. Suddenly stopping the medication might trigger severe chest pain or a heart attack, showing a physical dependency has formed.
  • Some studies suggest taking a break from nitrates for 10-12 hours to avoid developing this tolerance. However, this could lead to more chest pain or decreased ability to exercise for some. Rebound effects, like worsening symptoms after stopping Nitro-Dur, are rare but not well-studied.

Side Effects

Nitro-Dur may cause side effects for some users. Common Nitroglycerin side effects can include headaches, dizziness, lightheadedness, and mild skin irritation at the site of the patch application. These side effects are usually mild and tend to resolve on their own over time. However, if they persist or worsen, it is recommended to consult a healthcare professional.

There are also more serious side effects associated with Nitro-Dur that may require immediate medical attention. These can include worsening chest pain, pounding heartbeats or fluttering in the chest, slow heart rate, and a lightheaded feeling like one might pass out. In addition, Nitro-Dur can cause heart attack symptoms, such as chest pain or pressure, pain spreading to the jaw or shoulder, nausea, and sweating. If you or someone you know is taking Nitro-Dur and experiences any of these serious side effects, seeking medical advice immediately is important.

References:

  1. Nitro-Dur (Nitroglycerin Transdermal) Product Monograph. Whitehouse Station, NJ: Merck & Co., Inc; 2014.
  2. Nitro-Dur (Nitroglycerin Transdermal) Drug Label Information. Orlando, FL: Ingenus Pharmaceuticals, LLC; 2022.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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