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Nextstellis (Drospirenone and Estetrol)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Nextstellis is an oral birth control pill containing drospirenone, a progestin, and estetrol, an estrogen, for the prevention of pregnancy. 

Fact Table







Legal status


Chemical Name


Elimination half-life

24–27 h

Dosage (Strength)






Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


Nexstellis is available in a blister pack of 28 tablets:

  • 24 pink active tablets. Each pink tablet has 3 mg of drospirenone and 14.2 mg of estetrol.
  • 4 white inactive tablets

Take one tablet by mouth every day. Take it at the same time each day. Follow your prescription's instructions. If you have any questions, talk to your doctor or pharmacist.


Drospirenone and Estetrol are contained in each pink tablet.


  • Avoid taking Nexstellis if you smoke and are 35 years old or older.
  • Avoid taking Nextstellis if you have active or a history of blood clots, uncontrolled high blood pressure, a heart attack, a stroke, or certain heart valve problems.
  • Avoid taking Nextstelllis if you have active or a history of hormonally-sensitive cancer such as breast cancer.
  • Avoid taking Nexstellis if you have migraines with aura.
  • Avoid taking Nexstellis if you have diabetes with high blood pressure or end-organ damage or if you have had diabetes for more than 20 years.
  • Avoid taking Nextstellis if you have liver problems, including a liver tumor, liver cancer, acute hepatitis, or decompensated liver cirrhosis.
  • Avoid taking Nextstellis with hepatitis C medications containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir.
  • Avoid taking Nexstellis if you have vaginal bleeding from an unknown cause.
  • Avoid taking Nextstellis if you have kidney problems.
  • Avoid taking Nexstellis if you have adrenal insufficiency.



See full prescribing information for complete boxed warning.

  • Females over 35 years old who smoke should not use NEXTSTELLIS 
  • Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC) use.
  • Before you start Nextstellis, talk to your doctor:
    • About all the medications you take. These include all prescription and over-the-counter medications, vitamins, and herbal supplements. 
    • About any allergies you may have.
    • About your medical conditions.
    • If you are pregnant, suspect that you are pregnant, or plan to become pregnant.
    • If you are currently breastfeeding or plan to breastfeed.
  • Your risk for blood clots, a heart attack, or a stroke can be increased with the use of Nextstellis. Your risk for cardiovascular events should be evaluated before you start taking Nexstellis.
  • High potassium levels in your blood can occur with the use of Nextstellis. Immediately contact your doctor if you experience muscle fatigue, weakness, irregular heart rhythms, nausea, or paralysis. 
  • High blood pressure can be caused by Nexstellis. It is recommended that you periodically check your blood pressure while taking Nexstellis.
  • Severe or persistent migraines can occur with the use of Nexstellis.
  • Liver problems can occur with the use of Nexstellis.
  • The growth of hormonally-sensitive cancers such as breast cancer can be promoted by Nexstellis.
  • Decreased glucose intolerance in women who have prediabetes or diabetes can occur with the use of Nexstellis.
  • Triglyceride levels can increase with the use of Nexstellis in women who have high triglyceride levels or have a family history of high triglyceride levels. This can cause pancreatitis.
  • Gallbladder problems and cholestasis can occur with the use of Nextstellis.
  • Irregular vaginal bleeding or no menstruation can occur with the use of Nexstellis.

Side Effects

Nextstellis can cause side effects that include but are not limited to acne, breast tenderness, decreased sex drive, headache, mood changes, weight gain, and painful menstruation.

Call your doctor right away if you experience negative or persistent side effects.


  1. Nexstellis. Greenville, NC: Mayne Pharma; 2021.
  2. Nextstellis (drospirenone and estetrol tablets) 3 mg/14.2 mg. Accessed February 9, 2022.
  3. High potassium (hyperkalemia). Mayo Clinic. November 14, 2020. Accessed February 9, 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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