Neupogen (Filgrastim)

Prescription medicineOnly Available By Prescription

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Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Neupogen is a prescription medication to prevent febrile neutropenia and is prescribed for people who are having chemotherapy treatments and need to increase their low white blood cell count. Filgrastim is a G-CSF class drug that stimulates bone marrow so that white blood cells are produced in greater numbers and mature faster into neutrophils ready to fight bacteria in the bloodstream and limit the chances of a neutropenia infection. Buy Neupogen from Canada and Canada Drugs Direct and get the best price on it.

Fact Table

Formula

C845H1343N223O243S9

License

US FDA, US DailyMed, EU EMA

Bioavailability

60 to 70%

Legal status

Rx-Only

Chemical Name

Filgrastim

Elimination half-life

3.5 hours

Dosage (Strength)

300mcg/mL, 480mcg/1.6mL

Pregnancy

Consult a healthcare provider for advice

Brands

Neupogen

Protein binding

Unknown

PubChem CID

Not available because this is not a discrete structure

MedlinePlus

a692033

ChEBI

Not Assigned

ATC code

L03AA02

DrugBank

DB00099

KEGG

D03235

Routes of administration

Intraveneous, subcutaneous

Directions

General:

A Neupogen injection is to be administered subcutaneously (under skin) daily during a chemotherapy cycle and at the same time each day. Do not administer anytime within 24 hours prior to or following a chemotherapy session.

Possible sites for the injection are the upper arm, thigh (front of upper legs), buttocks, or stomach (abdomen) but excluding a 2” radius around the navel.

Administration:

Remove syringe tray from carton and let it warm up at room temperature for 30 minutes prior to injection.

Open tray by pulling back cover and use thumb and index finger to grab syringe from the tray.

Along with syringe, assemble the following materials that will also be required for your injection:

  • Alcohol wipe
  • Cotton ball or gauze pad
  • Adhesive bandage
  • Sharps disposal container

Clean administration site.

Hold prefilled syringe by barrel and pull gray needle cap off.

Confirm dosage (full / partial) indicated on syringe matches the indicated dose you are to take.

Point needle up and tap gently to force air to rise to the top.

Push plunger rod up to the line on the barrel that matches your prescribed dose.

Pinch injection site to create firm surface on the skin.

Hold pinch while inserting needle into skin at 45 to 90 degrees.

Push syringe plunger rod until it reaches bottom.

Once injection is complete pull syringe out and away from skin.

Pull orange safety guard over needle and hear it click into position before disposing in sharps container.

Ingredients

The active ingredient in Neupogen is Filgrastim.

Cautions

Inform your doctor of any history of kidney dysfunction, sickle cell disorders, latex allergies, or if you are receiving radiation therapy before beginning on Neupogen.

Neupogen is to be stored in a refrigerator between 36 and 46 degrees Fahrenheit (2-8 Celsius) and do not freeze.

Women who are pregnant or breastfeeding should not use this medication unless approved to do so by their doctor.

Use of Neupogen can cause a serious lung problem (ARDS – acute respiratory distress syndrome) or capillary leak syndrome. Seek medical assistance without delay if you have fever, shortness of breath, stuffy or runny nose followed by tiredness, increased thirst, decreased urination following use of this medication.

Spleen enlargement or a rupturing of the spleen may also be possible with the Neupogen injection, and you should seek medical assistance if you have pain in the left side of your upper stomach or in your left shoulder following an injection.

Keep out of reach of children even while refrigerated.

Interactions

Negative drug interactions are a possibility between Neupogen and other Rx medications, including acyclovir, albuterol, lorazepam, diphenhydramine, ciprofloxacin, dexamethasone, hydromorphone, gabapentin, furosemide, leucovorin, levofloxacin, levothyroxine, lorazepam, esomeprazole, omeprazole, ondansetron, oxycodone, pantoprazole, prednisone, prochlorperazine, lenalidomide, trazodone, and ondansetron.

Inform your doctor of all medications you are currently taking before getting a prescription and proceeding to buy Neupogen online.

Side Effects

Neupogen side effects are a possibility, and some users may experience fever, nosebleeds, cough, bone pain, breathing difficulties, anemia, diarrhea, headache, numbness, rash, or hair loss. If side effects are seen it may be best to stop use and talk to your doctor again to discuss neutropenia prevention medication alternatives.


Frequently Asked Questions about Neupogen


What is Neupogen used for?

Neupogen helps increase white blood cells, mainly neutrophils, to fight infections in people with low levels due to chemotherapy, radiation therapy, or certain bone marrow conditions.


How is Neupogen given?

It's usually injected under the skin (subcutaneously) or into a vein (intravenously). Your doctor will determine the dosage and schedule based on your needs.


Does Neupogen have side effects?

Yes, common side effects include bone pain, fatigue, headache, nausea, and injection site reactions. More serious side effects can occur, so consult your doctor about any worrying symptoms.


Who shouldn't take Neupogen?

People with certain medical conditions, allergies to filgrastim or its components, pregnant or breastfeeding women, and some children shouldn't take Neupogen. Discuss your medical history with your doctor before starting.


Can Neupogen cause cancer?

While studies haven't conclusively linked Neupogen to increased cancer risk, it's important to discuss this concern with your doctor if you have a history of cancer or risk factors.


Does Neupogen affect fertility?

There's limited data on Neupogen's impact on fertility. Talk to your doctor if you're concerned about its potential effects on pregnancy or sperm production.


How long does it take for Neupogen to work?

It can take several days for Neupogen to increase white blood cell counts. Regular blood tests will monitor your progress.


Can I stop taking Neupogen on my own?

No, always follow your doctor's instructions for stopping Neupogen, as abruptly stopping can worsen your condition.


What should I do if I miss a dose?

Contact your doctor for guidance on missed doses. Don't double up on the next dose without consulting them.


Are there any lifestyle changes I need to make while taking Neupogen?

Practice good hygiene to avoid infections, get enough rest, and inform your doctor about any new or worsening symptoms.


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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