Myleran (Busulfan)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
2mg
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Myleran (busulfan) is a potent alkylating agent indicated for the palliative treatment of chronic myelogenous leukemia

Myleran (busulfan) 2 mg oral tablets are what are supplied.


Fact Table

Formula

C6H14O6S2

License

US FDA, EU EMA, US DailyMed

Bioavailability

60–80%

Legal status

Rx-Only

Chemical Name

Busulfan

Elimination half-life

2.5 hours

Dosage (Strength)

2mg

Pregnancy

Contraindicated

Brands

Myleran

Protein binding

32.4%

PubChem CID

2478

MedlinePlus

a682248

ChEBI

28901

ATC code

L01AB01

DrugBank

DB01008

KEGG

D00248

Routes of administration

By mouth

Directions

Myleran dosage for remission induction in adults: 4 mg to 8 mg by mouth by mouth daily

Ingredients

The active ingredient in each Myleran tablet is Busulfan.

Contraindications

Do not take Myleran if you have not been definitively diagnosed with chronic myelogenous leukemia. 

If you are allergic to busulfan or any of the other ingredients or excipients in Myleran, do not take the medication. Tell your doctor about any allergies you have.

Cautions

MYLERAN is a potent drug. It should not be used unless a diagnosis of chronic myelogenous leukemia has been adequately established and the responsible physician is knowledgeable in assessing response to chemotherapy.

MYLERAN can induce severe bone marrow hypoplasia. Reduce or discontinue the dosage immediately at the first sign of any unusual depression of bone marrow function as reflected by an abnormal decrease in any of the formed elements of the blood. A bone marrow examination should be performed if the bone marrow status is uncertain.

SEE WARNINGS FOR INFORMATION REGARDING BUSULFAN-INDUCED LEUKEMOGENESIS IN HUMANS.

Tell your doctor about all the medications you take, including any that you take over-the-counter. Myerlan can interact with certain medications which can cause unpleasant or serious reactions.

Once you are prescribed and buy Myleran, Myleran may induce bone marrow failure which can cause a decrease in blood cell counts. Extreme caution should be used if your bone marrow reserve has been reduced.

Myleran can cause bronchopulmonary dysplasia with pulmonary fibrosis. Seek medical attention right away if you develop a cough, shortness of breath, and a fever. 

Myleran may cause cellular dysplasia in many organs, including the lungs. 

Malignant tumors and acute leukemias have been seen in patients who received Myleran. 

Premenopausal patients who have received Myleran may experience suppression of the ovaries and absence of menstruation with symptoms of menopause.

Male patients who receive treatment with Myleran may experience sterility, testicular atrophy, and the absence of sperm.

Hepatic veno-occlusive disease can occur with Myleran treatment, especially if taken with cyclophosphamide or other chemotherapy. Liver enzymes should be evaluated.

Some patients with thalassemia who have received Myleran and cyclophosphamide have experienced cardiac tamponade.

Tell your doctor if you are pregnant or plan to become pregnant. Myleran can cause harm to an unborn baby.

Tell your doctor if you are breastfeeding or plan to breastfeed. 

Side Effects

Side effects may occur with the use of Myleran, and some side effects can be severe. Side effects may include:

  • Low blood counts
  • Infection
  • Vision problems
  • Breathing problems
  • Nausea
  • Vomiting
  • Cough
  • Mouth sores
  • Skin redness, blistering, or peeling 
  • Rapid heartbeat
  • Irregular heartbeat
  • Seizures
  • Swelling
  • Weakness or tiredness
  • Yellowing of the skin or eyes

Tell your doctor right away if you experience side effects that are bothersome or persist. 

References:

  1. Myleran (busulfan). Research Triangle Park, NC: DSM Pharmaceuticals, Inc.; 2003.
  2. Myleran. GoodRx. Accessed January 3, 2022.


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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