Mycobutin (Rifabutin)

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Mycobutin, also known as Rifabutin, is an antibiotic that targets a range of bacterial infections. It belongs to the rifamycin antimycobacterial group of medications. Rifabutin works by blocking the activity of RNA polymerase in bacteria, which hinders their ability to create necessary proteins and reproduce. It is frequently recommended for preventing and treating a severe infection known as Mycobacterium avium complex (MAC) in individuals with HIV. Rifabutin can also be used in the treatment of tuberculosis when other therapies are not appropriate.

Directions

Mycobutin comes in the form of capsules, and patients should take it exactly as their doctor prescribes. The standard dosage is typically 300 mg taken orally once a day or 150 mg twice daily, and it should not exceed 300 mg per day. It’s important to maintain a consistent schedule while taking the medication to ensure the best possible effect and to report any severe reactions to a healthcare provider immediately.

Ingredients

Mycobutin capsules, each containing 150 mg of the active ingredient Rifabutin, also include various inactive substances, such as microcrystalline cellulose, magnesium stearate, and silica gel, which support the medication's delivery and stability.

Contraindications

Individuals with a known hypersensitivity to Rifabutin or any other rifamycins should not take Mycobutin, as allergic reactions can be severe.

Cautions

  • Before beginning treatment with Mycobutin, it's important to discuss the following with your healthcare provider:
    • Your current health conditions
    • Any allergies you may have
    • All medications you are currently using
    • Whether you are pregnant or breastfeeding
  • Mycobutin should not be used alone for treating active tuberculosis. It could cause tuberculosis to become resistant to both Mycobutin and similar drugs.
  • When used with clarithromycin for treating Mycobacterium avium complex (MAC), a lower dose of Mycobutin is recommended due to increased drug levels in the blood.
  • Be vigilant for hypersensitivity reactions like severe allergies or flu-like symptoms. If these occur, Mycobutin should be discontinued and appropriate medical support provided.
  • Monitor for eye inflammation (uveitis), especially when used with clarithromycin or certain antifungal drugs. If suspected, refer to an ophthalmologist and consider pausing Mycobutin treatment.
  • Clostridioides difficile associated diarrhea (CDAD) can occur with nearly all antibacterial agents, including Mycobutin. If diarrhea occurs, evaluate for CDAD and manage with appropriate treatment.
  • Watch for severe skin reactions such as Stevens-Johnson syndrome or drug reaction with eosinophilia and systemic symptoms (DRESS). If skin rash worsens, stop Mycobutin and get medical help.

Side Effects

Mycobutin side effects may include stomach pain, weakness, chest discomfort, fever, headache, and generalized pain. Blood-related issues such as leucopenia (low white blood cell count) and anemia (low red blood cell count) may also occur. Digestive problems like diarrhea, dyspepsia (indigestion), and nausea are sometimes reported. In addition, patients may experience muscle and joint aches, insomnia, skin rashes, taste perversion, and discolored urine due to the medication.

More severe side effects of Mycobutin include neutropenia, which is a significant decrease in white blood cells that can raise the risk of infection, and thrombocytopenia, characterized by a low platelet count that may result in bleeding problems. Gastrointestinal issues like Clostridioides difficile colitis, a severe colon infection, have also been reported. Immediate medical attention is necessary for hypersensitivity reactions such as rash, trouble breathing, and swelling of the face or throat. Watch for these reactions and promptly consult their healthcare provider if you experience severe or persistent symptoms.

References:

  1. Mycobutin (Rifabutin) Product Monograph. New York, NY: Pfizer Laboratories; 2021.
  2. Mycobutin (Rifabutin) Drug Label Information. New York, NY: Pfizer Laboratories; 2021.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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