mRESVIA (mRNA-1345)

Prescription medicineOnly Available By Prescription

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Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

mRESVIA is an innovative mRNA-based vaccine developed by Moderna, designed to protect adults aged 60 years and older from lower respiratory tract disease (LRTD) caused by respiratory syncytial virus (RSV). By encoding the stabilized prefusion F glycoprotein of RSV, mRESVIA prompts the body to produce an immune response against both RSV-A and RSV-B subtypes. For individuals seeking to buy mRESVIA, it's essential to consult healthcare providers to understand its benefits and suitability.

Fact Table

Formula

N/A (mRNA-based)

License

US FDA (2024)

Bioavailability

Not applicable (vaccine)

Legal status

Prescription only (Rx)

Chemical Name

Respiratory Syncytial Virus Vaccine, mRNA (mRNA-1345)

Elimination half-life

Short (mRNA degraded rapidly in vivo)

Dosage (Strength)

One 0.5 mL intramuscular injection (containing 50 µg mRNA)

Pregnancy

Not recommended without medical consultation

Brands

mRESVIA

Protein binding

Not applicable

PubChem CID

Not listed

MedlinePlus

a621035

ChEBI

Not listed

ATC code

J07BH06

DrugBank

DB17975

KEGG

D12572

Routes of administration

Intramuscular injection

Directions

Administered as a single 0.5 mL intramuscular injection, mRESVIA is supplied in prefilled syringes for ease of use. The vaccine should be stored frozen between -40°C to -15°C and thawed prior to administration. Once thawed, it can be stored refrigerated at 2°C to 8°C for up to 30 days. Healthcare professionals should follow proper storage and handling protocols to maintain vaccine efficacy.

Ingredients

Each 0.5 mL dose of mRESVIA contains:

  • 50 micrograms of nucleoside-modified mRNA encoding the RSV prefusion F glycoprotein
  • Lipid nanoparticles (LNPs) for mRNA delivery
  • Excipients including SM-102, cholesterol, DSPC, PEG2000-DMG, tromethamine, tromethamine hydrochloride, acetic acid, sodium acetate, and sucrose

The formulation is preservative-free and appears as a white to off-white suspension.

Cautions

Before administering the mRESVIA vaccine, healthcare providers should assess individuals for potential hypersensitivity reactions. The vaccine's safety and efficacy have not been established in populations under 60 years of age. As with all vaccines, immunization with mRESVIA may not protect all recipients. Monitoring for adverse reactions post-vaccination is recommended.

Contraindications

mRESVIA is contraindicated in individuals with a history of severe allergic reactions (e.g., anaphylaxis) to any component of the vaccine.

Side Effects

Common side effects observed in clinical trials include:

  • Injection-site pain (55.9%)
  • Fatigue (30.8%)
  • Headache (26.7%)
  • Myalgia (25.6%)
  • Arthralgia (21.7%)
  • Axillary swelling or tenderness (15.2%)
  • Chills (11.6%)

These reactions are generally mild to moderate in intensity and resolve within a few days post-vaccination.

Frequently Asked Questions about mRESVIA (mRNA-1345)


What is mRESVIA (mRNA-1345)?

mRESVIA is an mRNA vaccine developed to prevent respiratory syncytial virus (RSV) infection in adults aged 60 and older.


How does mRESVIA work?

mRESVIA uses mRNA technology to instruct your cells to produce a protein that resembles a key RSV protein, triggering an immune response without causing infection.


How effective is mRESVIA against RSV?

Clinical trials showed that mRESVIA is approximately 84% effective at preventing RSV-associated lower respiratory tract disease in adults 60 years and older.


What are the common side effects of mRESVIA?

Common side effects include injection site pain, fatigue, headache, muscle pain, joint pain, and mild fever, typically resolving within a few days.


Who should receive the mRESVIA vaccine?

mRESVIA is recommended for adults 60 years and older who are at increased risk for RSV disease.


Is mRESVIA a one-time vaccine or will I need boosters?

Current recommendations suggest one dose, but ongoing studies are evaluating whether booster doses may be needed in future seasons.


Can I receive mRESVIA at the same time as other vaccines?

Yes, mRESVIA can generally be administered alongside other vaccines, including the seasonal flu vaccine and COVID-19 vaccines.


What is RSV and why should older adults be concerned about it?

RSV is a common respiratory virus that can cause severe respiratory illness in older adults, potentially leading to hospitalization or death, especially in those with underlying health conditions.


When is the best time to get vaccinated with mRESVIA?

Ideally, vaccination should occur before the RSV season, which typically runs from fall through spring in most regions.


Who should not receive mRESVIA?

Individuals with a history of severe allergic reaction to any component of the vaccine should not receive mRESVIA, and those with certain medical conditions should consult their healthcare provider first.

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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